LY367385 HCl| CAS#198419-91-9 | mGlu1a Receptor Antagonist

MedKoo Cat#: 532163 | Name: LY367385 HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis.

Chemical Structure

LY367385 HCl

CAS#2829282-00-8

Theoretical Analysis

MedKoo Cat#: 532163

Name: LY367385 HCl

CAS#: 2829282-00-8

Chemical Formula: C10H12ClNO4

Exact Mass: 209.0688

Molecular Weight: 245.66

Elemental Analysis: C, 48.89; H, 4.92; Cl, 14.43; N, 5.70; O, 26.05

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 300.00	2 weeks
25mg	USD 800.00	2 weeks

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Related CAS #

198419-91-9 (free base) LY367385 HCl

Synonym

LY367385; LY 367385; LY-367385; LY367385 HCl; LY367385 hydrochloride

IUPAC/Chemical Name

4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]-3-methylbenzoic acid hydrochloride

InChi Key

IGKQWSUZDKTEPR-QRPNPIFTSA-N

InChi Code

InChI=1S/C10H11NO4.ClH/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15;/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15);1H/t8-;/m0./s1

SMILES Code

O=C(O)C1=CC=C([C@H](N)C(O)=O)C(C)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#S20G05M27

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

LY367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM.

In vitro activity:

TBD

In vivo activity:

LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid) have been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice both compounds produce a rapid, transient suppression of sound-induced clonic seizures (LY 367385: ED50 = 12 nmol, i.c.v., 5 min; AIDA: ED50 = 79 nmol, i.c.v., 15 min). Reference: Eur J Pharmacol. 1999 Feb 26;368(1):17-24. https://pubmed.ncbi.nlm.nih.gov/10096765/

	Solvent	mg/mL	mM
Solubility
	DMSO	125.0	508.84
	Water	12.5	50.88

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 245.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Chapman AG, Yip PK, Yap JS, Quinn LP, Tang E, Harris JR, Meldrum BS. Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24. doi: 10.1016/s0014-2999(99)00014-x. PMID: 10096765.

In vitro protocol:

TBD

In vivo protocol: