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MedKoo Cat#: 564069 | Name: RU-24969 hemisuccinate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU-24969 hemisuccinate is a potent serotonin SR-1A/SR-1B and moderate SR-2C agonist.

Chemical Structure

RU-24969 hemisuccinate
RU-24969 hemisuccinate
CAS#66611-27-6 (succinate)

Theoretical Analysis

MedKoo Cat#: 564069

Name: RU-24969 hemisuccinate

CAS#: 66611-27-6 (succinate)

Chemical Formula: C32H38N4O6

Exact Mass: 574.2791

Molecular Weight: 574.68

Elemental Analysis: C, 66.88; H, 6.67; N, 9.75; O, 16.70

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 390.00 2 Weeks
25mg USD 670.00 2 Weeks
50mg USD 1,060.00 2 Weeks
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Related CAS #
107008-28-6 (free base) 66611-27-6 (succinate)
Synonym
RU-24969; RU24969; RU 24969; RU 4969 hemisuccinate; RU24969 hemisuccinate; RU-24969 hemisuccinate
IUPAC/Chemical Name
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole hemisuccinate
InChi Key
BNYJLRQAWCQJOM-UHFFFAOYSA-N
InChi Code
InChI=1S/2C14H16N2O.C4H6O4/c2*1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10;5-3(6)1-2-4(7)8/h2*2-4,8-9,15-16H,5-7H2,1H3;1-2H2,(H,5,6)(H,7,8)
SMILES Code
COC1=CC2=C(NC=C2C3=CCNCC3)C=C1.O=C(O)CCC(O)=O.COC4=CC5=C(NC=C5C6=CCNCC6)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 574.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Effects of repeated RU 24969 treatment on the locomotor activity, motoric capacity, and axillary temperatures of male and female preweanling rats. Behav Brain Res. 2021 Feb 1;398:112982. doi: 10.1016/j.bbr.2020.112982. Epub 2020 Nov 6. PMID: 33166571; PMCID: PMC8384048. 5: McDougall SA, Robinson JAM, Ramirez EL, Diaz HA. Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats. Pharmacol Biochem Behav. 2020 Feb;189:172857. doi: 10.1016/j.pbb.2020.172857. Epub 2020 Jan 17. PMID: 31958472. 6: Webster JI, Harper DN, Schenk S. Generalization of serotonin and dopamine ligands to the discriminative stimulus effects of different doses of ±3,4-methylenedioxymethamphetamine. Behav Pharmacol. 2017 Jun;28(4):245-254. doi: 10.1097/FBP.0000000000000282. PMID: 27922542. 7: Schenk S, Foote J, Aronsen D, Bukholt N, Highgate Q, Van de Wetering R, Webster J. Serotonin antagonists fail to alter MDMA self-administration in rats. Pharmacol Biochem Behav. 2016 Sep;148:38-45. doi: 10.1016/j.pbb.2016.06.002. Epub 2016 Jun 2. PMID: 27264435. 8: Aronsen D, Schenk S. MDMA self-administration fails to alter the behavioral response to 5-HT(1A) and 5-HT(1B) agonists. Psychopharmacology (Berl). 2016 Apr;233(7):1323-30. doi: 10.1007/s00213-016-4226-9. Epub 2016 Feb 9. PMID: 26856854. 9: Aronsen D, Bukholt N, Schenk S. Repeated administration of the 5-HT₁B/₁A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT₁A and 5-HT₁B receptor mechanisms. Psychopharmacology (Berl). 2016 Apr;233(8):1339-47. doi: 10.1007/s00213-016-4225-x. Epub 2016 Feb 9. PMID: 26856853. 10: Aronsen D, Webster J, Schenk S. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4. doi: 10.1016/j.pbb.2014.05.008. Epub 2014 May 15. PMID: 24844705. 11: Kantak PA, Bobrow DN, Nyby JG. Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG). Behav Pharmacol. 2014 Feb;25(1):71-9. doi: 10.1097/FBP.0000000000000013. PMID: 24257436. 12: Helms CM, McCracken AD, Heichman SL, Moschak TM. Ovarian hormones and the heterogeneous receptor mechanisms mediating the discriminative stimulus effects of ethanol in female rats. Behav Pharmacol. 2013 Apr;24(2):95-104. doi: 10.1097/FBP.0b013e32835efc5f. PMID: 23399883; PMCID: PMC3864632. 13: Clément Y, Le Guisquet AM, Venault P, Chapouthier G, Belzung C. Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation. PLoS One. 2009 Nov 11;4(11):e7745. doi: 10.1371/journal.pone.0007745. PMID: 19907641; PMCID: PMC2770638. 14: Brookshire BR, Jones SR. Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice. Pharmacol Biochem Behav. 2009 Nov;94(1):194-203. doi: 10.1016/j.pbb.2009.08.008. Epub 2009 Aug 19. PMID: 19698737; PMCID: PMC2768771. 15: Fontana AC, Sonders MS, Pereira-Junior OS, Knight M, Javitch JA, Rodrigues V, Amara SG, Mortensen OV. Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin. Eur J Pharmacol. 2009 Aug 15;616(1-3):48-57. doi: 10.1016/j.ejphar.2009.06.023. Epub 2009 Jun 21. PMID: 19549517; PMCID: PMC2746412. 16: Young R, Glennon RA. S(-)Propranolol as a discriminative stimulus and its comparison to the stimulus effects of cocaine in rats. Psychopharmacology (Berl). 2009 Apr;203(2):369-82. doi: 10.1007/s00213-008-1317-2. Epub 2008 Sep 16. PMID: 18795268. 17: O'Dell LE, Manzardo AM, Polis I, Stouffer DG, Parsons LH. Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration. J Neurochem. 2006 Dec;99(5):1363-76. doi: 10.1111/j.1471-4159.2006.04163.x. PMID: 17074068. 18: Wesołowska A, Nikiforuk A, Chojnacka-Wójcik E. Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. Eur J Pharmacol. 2006 Jul 10;541(1-2):57-63. doi: 10.1016/j.ejphar.2006.04.049. Epub 2006 May 7. PMID: 16765343. 19: Unger EL, Eve DJ, Perez XA, Reichenbach DK, Xu Y, Lee MK, Andrews AM. Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice. Neurobiol Dis. 2006 Feb;21(2):431-43. doi: 10.1016/j.nbd.2005.08.005. Epub 2005 Oct 14. PMID: 16230020. 20: Bourin M, Masse F, Hascoët M. Evidence for the activity of lamotrigine at 5-HT(1A) receptors in the mouse forced swimming test. J Psychiatry Neurosci. 2005 Jul;30(4):275-82. PMID: 16049571; PMCID: PMC1160563.

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NSC704342

NSC704342