Ro 8-4304 HCl | CAS#1312991-77-7 |195988-65-9 | NMDA receptor antagonist

MedKoo Cat#: 532573 | Name: Ro 8-4304 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 8-4304 hydrochloride is a NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Ro 8-4304 hydrochloride exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine.

Chemical Structure

Ro 8-4304 hydrochloride

CAS#1312991-77-7 (Ro8-4304 HCl); 195988-65-9 (Ro8-4304).

Theoretical Analysis

MedKoo Cat#: 532573

Name: Ro 8-4304 hydrochloride

CAS#: 1312991-77-7 (Ro8-4304 HCl); 195988-65-9 (Ro8-4304).

Chemical Formula: C21H24ClFN2O3

Exact Mass: 406.1459

Molecular Weight: 406.88

Elemental Analysis: C, 61.99; H, 5.95; Cl, 8.71; F, 4.67; N, 6.89; O, 11.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1312991-77-7 (Ro8-4304 HCl); 195988-65-9 (Ro8-4304).

Synonym

Ro 8-4304; Ro84304; Ro-8-4304; Ro 8-4304 hydrochloride; Ro 8-4304 HCl.

IUPAC/Chemical Name

4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride

InChi Key

MQOXWHKUQOFFJW-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H23FN2O3.ClH/c22-18-5-1-15(2-6-18)16-9-11-24(12-10-16)13-19(25)14-27-20-7-3-17(4-8-20)21(23)26;/h1-9,19,25H,10-14H2,(H2,23,26);1H

SMILES Code

O=C(N)C1=CC=C(OCC(O)CN2CC=C(C3=CC=C(F)C=C3)CC2)C=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 406.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kew JN, Trube G, Kemp JA. State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br J Pharmacol. 1998 Feb;123(3):463-72. PubMed PMID: 9504387; PubMed Central PMCID: PMC1565193.