FGFR4 inhibitor 1 CAS#unknown | FGFR4 inhibitor

MedKoo Cat#: 463194 | Name: FGFR4 inhibitor 1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FGFR4 inhibitor is a novel, covalent, highly potent, and exquisitely specific FGFR4 inhibitor.

Chemical Structure

FGFR4 inhibitor 1

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463194

Name: FGFR4 inhibitor 1

CAS#: unknown

Chemical Formula: C27H24Cl2N6O3

Exact Mass: 550.1287

Molecular Weight: 551.43

Elemental Analysis: C, 58.81; H, 4.39; Cl, 12.86; N, 15.24; O, 8.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

FGFR4 inhibitor 1;

IUPAC/Chemical Name

N-(2-((6-(2-((2,6-dichloro-3,5-dimethoxyphenyl)amino)pyridin-3-yl)pyrimidin-4-yl)amino)-3-methylphenyl)acrylamide

InChi Key

ZQYUWUUBHKOFPC-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H24Cl2N6O3/c1-5-22(36)33-17-10-6-8-15(2)25(17)34-21-12-18(31-14-32-21)16-9-7-11-30-27(16)35-26-23(28)19(37-3)13-20(38-4)24(26)29/h5-14H,1H2,2-4H3,(H,30,35)(H,33,36)(H,31,32,34)

SMILES Code

C=CC(NC1=CC=CC(C)=C1NC2=NC=NC(C3=CC=CN=C3NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 551.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu PCC, Koblish H, Wu L, Bowman K, Diamond S, DiMatteo D, Zhang Y, Hansbury M, Rupar M, Wen X, Collier P, Feldman P, Klabe R, Burke KA, Soloviev M, Gardiner C, He X, Volgina A, Covington M, Ruggeri B, Wynn R, Burn TC, Scherle P, Yeleswaram S, Yao W, Huber R, Hollis G. INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models. PLoS One. 2020 Apr 21;15(4):e0231877. doi: 10.1371/journal.pone.0231877. PMID: 32315352; PMCID: PMC7313537. 2: Quintanal-Villalonga Á, Ferrer I, Guruceaga E, Cirauqui C, Marrugal Á, Ojeda L, García S, Zugazagoitia J, Muñoz-Galván S, Lopez-Rios F, Montuenga L, Vicent S, Molina-Pinelo S, Carnero A, Paz-Ares L. FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy. EBioMedicine. 2020 Mar;53:102683. doi: 10.1016/j.ebiom.2020.102683. Epub 2020 Feb 27. PMID: 32114392; PMCID: PMC7047190. 3: Cai Q, Wu G, Zhu M, Ge H, Xue C, Zhang Q, Cheng B, Xu S, Wu P. FGF6 enhances muscle regeneration after nerve injury by relying on ERK1/2 mechanism. Life Sci. 2020 May 1;248:117465. doi: 10.1016/j.lfs.2020.117465. Epub 2020 Feb 24. PMID: 32105707.