MedKoo Cat#: 413903 | Name: Doxylamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Doxylamine is a Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.

Chemical Structure

Doxylamine
Doxylamine
CAS#469-21-6 (free base)

Theoretical Analysis

MedKoo Cat#: 413903

Name: Doxylamine

CAS#: 469-21-6 (free base)

Chemical Formula: C17H22N2O

Exact Mass: 270.1732

Molecular Weight: 270.38

Elemental Analysis: C, 75.52; H, 8.20; N, 10.36; O, 5.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Doxylamine; Dossilamina; Doxylaminum; Doxilminio; (±)-Doxylamine;
IUPAC/Chemical Name
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
InChi Key
HCFDWZZGGLSKEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
SMILES Code
CC(C1=NC=CC=C1)(OCCN(C)C)C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Doxylamine/pyridoxine for nausea and vomiting in pregnancy. Drug Ther Bull. 2019 Mar;57(3):38-41. doi: 10.1136/dtb.2018.000053. Epub 2019 Jan 31. PMID: 30705026. 2: Brott NR, Reddivari AKR. Doxylamine. 2021 Jan 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 31869110. 3: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Doxylamine. 2017 Jan 16. PMID: 31644135. 4: Persaud N, Meaney C, El-Emam K, Moineddin R, Thorpe K. Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. PLoS One. 2018 Jan 17;13(1):e0189978. doi: 10.1371/journal.pone.0189978. PMID: 29342163; PMCID: PMC5771578. 5: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Doxylamine. 2018 Dec 3. PMID: 29999680. 6: Burchakov DI. Doksilamin i melatonin v korrektsii narusheniĭ sna v ginekologicheskoĭ praktike [Doxylamine and melatonin in treatment of sleep disruption in gynecological practice]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(4. Vyp. 2):67-72. Russian. doi: 10.17116/jnevro20181184267. PMID: 30059054. 7: Abraham O, Schleiden L, Albert SM. Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep. Int J Clin Pharm. 2017 Aug;39(4):808-817. doi: 10.1007/s11096-017-0467-x. Epub 2017 May 2. PMID: 28466395; PMCID: PMC5541127. 8: Abramowitz A, Miller ES, Wisner KL. Treatment options for hyperemesis gravidarum. Arch Womens Ment Health. 2017 Jun;20(3):363-372. doi: 10.1007/s00737-016-0707-4. Epub 2017 Jan 9. PMID: 28070660; PMCID: PMC7037589. 9: Hung CH, Shieh JP, Chiu CC, Wang JJ, Chen YW. Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. Pharmacol Rep. 2018 Jun;70(3):565-569. doi: 10.1016/j.pharep.2017.12.006. Epub 2017 Dec 20. PMID: 29679880. 10: Drugs for chronic insomnia. Med Lett Drugs Ther. 2018 Dec 17;60(1562):201-205. PMID: 30625122.