NSC-40738 | CAS#67-47-0 | sickle cell anemia

MedKoo Cat#: 529016 | Name: NSC-40738

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-40738 is potentially for the treatment of sickle cell anemia.

Chemical Structure

NSC-40738

CAS#67-47-0

Theoretical Analysis

MedKoo Cat#: 529016

Name: NSC-40738

CAS#: 67-47-0

Chemical Formula: C6H6O3

Exact Mass: 126.0317

Molecular Weight: 126.11

Elemental Analysis: C, 57.14; H, 4.80; O, 38.06

Price and Availability

Size	Price	Availability
5g	USD 250.00	2 Weeks
10g	USD 350.00	2 Weeks
25g	USD 550.00	2 Weeks

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Synonym

5-(Hydroxymethyl)furfural; 5-hydroxy methyl furfural; 5-HMF; 5HMF; 5 HMF; NSC-40738; NSC40738; NSC 40738

IUPAC/Chemical Name

5-(hydroxymethyl)furan-2-carbaldehyde

InChi Key

NOEGNKMFWQHSLB-UHFFFAOYSA-N

InChi Code

InChI=1S/C6H6O3/c7-3-5-1-2-6(4-8)9-5/h1-3,8H,4H2

SMILES Code

O=CC1=CC=C(CO)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.

In vitro activity:

After 5-HMF (5-Hydroxymetylfurfural) treatment for 24 h, the number of living cells decreased to 89.61 ± 0.48, 77.30 ± 0.57, 58.75 ± 0.36, and 19.61 ± 0.40% of the control, respectively. Apoptosis activated through both the death receptor and mitochondrial pathways was confirmed to be the primary mode of HMF-induced cell death. Further analysis revealed that the reactive oxygen species (ROS) levels in GES-1 cells increased 1.7-6.5 fold after exposure to 5-HMF. Reference: J Agric Food Chem. 2022 Mar 30;70(12):3852-3861. https://pubmed.ncbi.nlm.nih.gov/35311281/

In vivo activity:

Twelve male C57BL/6 mice (12-month-old, 38 ± 1 g) were randomly divided into the control group and the 5-HMF (5-Hydroxymethylfurfural) group. The 5-HMF group was treated with 5-HMF (1 mg/kg/day, respiratory exposure) for 12 months, whereas the control group was treated with equal amounts of sterile water. In the 5-HMF group, serum inflammatory factors IL-6, TNF-α, and CRP levels were significantly raised (p < 0.01). Mice in this group had higher frailty scores and significantly reduced grip strength (p < 0.001), slower weight gains, less WVgastrocnemius muscle masses, and lower sarcopenia indices (SI). Reference: Heliyon. 2023 Jan 22;9(2):e13217. https://pubmed.ncbi.nlm.nih.gov/36793951/

	Solvent	mg/mL	mM
Solubility
	DMSO	26.0	206.17
	Ethanol	2.5	19.82
	PBS (pH 7.2)	10.0	79.30

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 126.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Qiu Y, Lin X, Chen Z, Li B, Zhang Y. 5-Hydroxymethylfurfural Exerts Negative Effects on Gastric Mucosal Epithelial Cells by Inducing Oxidative Stress, Apoptosis, and Tight Junction Disruption. J Agric Food Chem. 2022 Mar 30;70(12):3852-3861. doi: 10.1021/acs.jafc.2c00269. Epub 2022 Mar 21. PMID: 35311281. 2. Vijayakumar K, Thirunanasambandham R. 5-Hydroxymethylfurfural inhibits Acinetobacter baumannii biofilms: an in vitro study. Arch Microbiol. 2021 Mar;203(2):673-682. doi: 10.1007/s00203-020-02061-0. Epub 2020 Oct 9. PMID: 33037454. 3. Xu T, Xia R, He F, Dong EH, Shen JM, Xu CC, Ji MH, Xu Q. 5-Hydroxymethylfurfural induces mice frailty through cell senescence-associated sarcopenia caused by chronic inflammation. Heliyon. 2023 Jan 22;9(2):e13217. doi: 10.1016/j.heliyon.2023.e13217. PMID: 36793951; PMCID: PMC9922977. 4. Zhang H, Jiang Z, Shen C, Zou H, Zhang Z, Wang K, Bai R, Kang Y, Ye XY, Xie T. 5-Hydroxymethylfurfural Alleviates Inflammatory Lung Injury by Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation. Front Cell Dev Biol. 2021 Dec 13;9:782427. doi: 10.3389/fcell.2021.782427. PMID: 34966742; PMCID: PMC8711100.

In vitro protocol:

In vivo protocol:

1. Xu T, Xia R, He F, Dong EH, Shen JM, Xu CC, Ji MH, Xu Q. 5-Hydroxymethylfurfural induces mice frailty through cell senescence-associated sarcopenia caused by chronic inflammation. Heliyon. 2023 Jan 22;9(2):e13217. doi: 10.1016/j.heliyon.2023.e13217. PMID: 36793951; PMCID: PMC9922977. 2. Zhang H, Jiang Z, Shen C, Zou H, Zhang Z, Wang K, Bai R, Kang Y, Ye XY, Xie T. 5-Hydroxymethylfurfural Alleviates Inflammatory Lung Injury by Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation. Front Cell Dev Biol. 2021 Dec 13;9:782427. doi: 10.3389/fcell.2021.782427. PMID: 34966742; PMCID: PMC8711100.

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