NSC-624206 hydrochloride | CAS# 13116-77-3 | Ubiquitin-activating enzyme (E1) inhibitor

MedKoo Cat#: 574824 | Name: NSC-624206 hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-624206 hydrochloride is an inhibitor of ubiquitin-activating enzyme (E1) that specifically blocks ubiquitin-thioester formation but has no effect on ubiquitin adenylation. Through this action, NSC-624206 prevents the ubiquitination and degradation of the tumor suppressor protein p27 in vitro.

Chemical Structure

NSC-624206 hydrochloride

CAS#13116-77-3

Theoretical Analysis

MedKoo Cat#: 574824

Name: NSC-624206 hydrochloride

CAS#: 13116-77-3

Chemical Formula: C19H33Cl2NS2

Exact Mass: 409.1431

Molecular Weight: 410.50

Elemental Analysis: C, 55.59; H, 8.10; Cl, 17.27; N, 3.41; S, 15.62

Price and Availability

Size	Price	Availability
5mg	USD 260.00	2 Weeks
10mg	USD 425.00	2 Weeks
25mg	USD 725.00	2 Weeks
50mg	USD 1,070.00	2 Weeks
100mg	USD 1,675.00	2 Weeks

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Related CAS #

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Synonym

NSC-624206 hydrochloride; NSC-624206 HCl

IUPAC/Chemical Name

N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-1-decanamine, monohydrochloride

InChi Key

JQHUAYXPNPTQRO-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H32ClNS2.ClH/c1-2-3-4-5-6-7-8-9-14-21-15-16-22-23-17-18-10-12-19(20)13-11-18;/h10-13,21H,2-9,14-17H2,1H3;1H

SMILES Code

ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM.

In vitro activity:

Several small-molecule inhibitors, including NSC624206, were identified and subsequently verified to prevent p27 ubiquitination in vitro. The mechanism of NSC624206 inhibition of p27 ubiquitination was further unraveled using the nucleotide exchange assays and shown to be due to antagonizing ubiquitin activating enzyme (E1). Reference: J Biomol Screen. 2012 Apr;17(4):421-34. https://pubmed.ncbi.nlm.nih.gov/22274912/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	Ethanol	4.6	11.22

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 410.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen. 2012 Apr;17(4):421-34. doi: 10.1177/1087057111433843. Epub 2012 Jan 24. PMID: 22274912; PMCID: PMC3339042.

In vitro protocol:

In vivo protocol:

TBD

1. Ungermannova, D., Parker, P.J., Nasveschuk, C.G., et al. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J. Biomol. Screen. 17(4), 421-434 (2012).