LG190178 | CAS#233268-81-0

MedKoo Cat#: 532111 | Name: LG190178

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG190178 is a vitamin D receptor (VDR) ligand that is a therapeutic agent for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.

Chemical Structure

LG190178

CAS#233268-81-0

Theoretical Analysis

MedKoo Cat#: 532111

Name: LG190178

CAS#: 233268-81-0

Chemical Formula: C28H42O5

Exact Mass: 458.3032

Molecular Weight: 458.64

Elemental Analysis: C, 73.33; H, 9.23; O, 17.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LG190178; LG 190178; LG-190178.

IUPAC/Chemical Name

3-[4-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]-2-methylphenoxy]propane-1,2-diol

InChi Key

AIKLCYAFOOBGEV-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H42O5/c1-8-28(9-2,21-10-12-24(19(3)14-21)32-17-23(30)16-29)22-11-13-25(20(4)15-22)33-18-26(31)27(5,6)7/h10-15,23,26,29-31H,8-9,16-18H2,1-7H3

SMILES Code

OCC(O)COC1=CC=C(C(CC)(C2=CC=C(OCC(O)C(C)(C)C)C(C)=C2)CC)C=C1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

LG190178 is a vitamin D receptor (VDR) ligand that is a therapeutic agent for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.

In vitro activity:

LG190178 is a novel non-secosteroidal ligand for VDR. Reference: Bioorg Med Chem Lett. 2008 Jan 1;18(1):120-3. https://pubmed.ncbi.nlm.nih.gov/18054230/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 458.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hakamata W, Sato Y, Okuda H, Honzawa S, Saito N, Kishimoto S, Yamashita A, Sugiura T, Kittaka A, Kurihara M. (2S,2'R)-analogue of LG190178 is a major active isomer. Bioorg Med Chem Lett. 2008 Jan 1;18(1):120-3. doi: 10.1016/j.bmcl.2007.11.007. Epub 2007 Nov 5. PMID: 18054230. 2. Peräkylä M, Malinen M, Herzig KH, Carlberg C. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. Mol Endocrinol. 2005 Aug;19(8):2060-73. doi: 10.1210/me.2004-0417. Epub 2005 Apr 28. PMID: 15860548.

In vitro protocol:

In vivo protocol:

TBD

1: Hakamata W, Sato Y, Okuda H, Honzawa S, Saito N, Kishimoto S, Yamashita A, Sugiura T, Kittaka A, Kurihara M. (2S,2'R)-analogue of LG190178 is a major active isomer. Bioorg Med Chem Lett. 2008 Jan 1;18(1):120-3. PubMed PMID: 18054230.