MedKoo Cat#: 562253 | Name: Mesyl Salvinorin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mesyl Salvinorin B is a selective and potent full KOP receptor agonist with fewer side effects (e.g., sedation or anhedonia) than classic KOP-r full agonists and a longer duration of action in mice than the structurally similar salvinorin A. It acts by preventing cocaine seeking and reducing excessive alcohol drinking via KOP-r-mediated mechanism.

Chemical Structure

Mesyl Salvinorin B
CAS#862073-79-8

Theoretical Analysis

MedKoo Cat#: 562253

Name: Mesyl Salvinorin B

CAS#: 862073-79-8

Chemical Formula: C22H28O9S

Exact Mass: 468.1454

Molecular Weight: 468.51

Elemental Analysis: C, 56.40; H, 6.02; O, 30.73; S, 6.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Mesyl Salvinorin B; Mesyl Salvinorin-B; Mesyl Sal B; MSB;
IUPAC/Chemical Name
Methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-9-[(methylsulfonyl)oxy]-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylate
InChi Key
JPQCLBRBPPZECE-VOVNARLJSA-N
InChi Code
InChI=1S/C22H28O9S/c1-21-7-5-13-20(25)30-16(12-6-8-29-11-12)10-22(13,2)18(21)17(23)15(31-32(4,26)27)9-14(21)19(24)28-3/h6,8,11,13-16,18H,5,7,9-10H2,1-4H3/t13-,14-,15-,16-,18-,21-,22-/m0/s1
SMILES Code
O=C([C@H](C[C@H](OS(=O)(C)=O)C([C@@]12[H])=O)[C@]1(C)CC[C@@]([C@]2(C)C[C@@H](C3=COC=C3)O4)([H])C4=O)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 468.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou Y, Crowley R, Prisinzano T, Kreek MJ. Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neurosci Lett. 2018 Feb 26;673:19-23. doi: 10.1016/j.neulet.2018.02.056. [Epub ahead of print] PubMed PMID: 29496608. 2: Zhou Y, Crowley RS, Ben K, Prisinzano TE, Kreek MJ. Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. Brain Res. 2017 May 1;1662:75-86. doi: 10.1016/j.brainres.2017.02.027. Epub 2017 Mar 2. PubMed PMID: 28263712; PubMed Central PMCID: PMC5398281. 3: Simonson B, Morani AS, Ewald AW, Walker L, Kumar N, Simpson D, Miller JH, Prisinzano TE, Kivell BM. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Br J Pharmacol. 2015 Jan;172(2):515-31. doi: 10.1111/bph.12692. Epub 2014 Jul 1. PubMed PMID: 24641310; PubMed Central PMCID: PMC4292965.