Synonym
Harmine; telepathine; Yageine; Yajeine; Banisterine; Leucoharmine.
IUPAC/Chemical Name
7-methoxy-1-methyl-9H-pyrido[3,4-b]-indole
InChi Key
BXNJHAXVSOCGBA-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
SMILES Code
CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Harmine reversibly inhibits monoamine oxidase A (MAO-A), DYRK1A & DYRK2, PPARγ, and cdc-like kinases (CLKs)
In vitro activity:
In vitro results suggested that Harmine possessed QS inhibitory effects on pyocyanin production, exocellular protease excretion, biofilm formation, and twitching motility of P. aeruginosa PA14, and in vivo results displayed Harmine's protective effect on C. elegans and mice infection models.
Reference:
Chen P, Qin J, Su HK, Du L, Zeng Q. Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa. BMC Infect Dis. 2024 Jul 31;24(1):760. doi: 10.1186/s12879-024-09639-9. PMID: 39085766; PMCID: PMC11293143.
In vivo activity:
In vitro results suggested that Harmine possessed QS inhibitory effects on pyocyanin production, exocellular protease excretion, biofilm formation, and twitching motility of P. aeruginosa PA14, and in vivo results displayed Harmine's protective effect on C. elegans and mice infection models.
Reference:
Chen P, Qin J, Su HK, Du L, Zeng Q. Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa. BMC Infect Dis. 2024 Jul 31;24(1):760. doi: 10.1186/s12879-024-09639-9. PMID: 39085766; PMCID: PMC11293143.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
42.0 |
197.87 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
212.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
In vitro protocol:
1: Wang P, Wood O, Choleva L, Liu H, Karakose E, Lambertini L, Pillard A, Wu V, Garcia-Ocana A, Scott DK, Kumar K, DeVita RJ, Stewart AF. Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells. bioRxiv [Preprint]. 2024 May 17:2024.05.17.594179. doi: 10.1101/2024.05.17.594179. PMID: 38798411; PMCID: PMC11118480.
2: Chen P, Qin J, Su HK, Du L, Zeng Q. Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa. BMC Infect Dis. 2024 Jul 31;24(1):760. doi: 10.1186/s12879-024-09639-9. PMID: 39085766; PMCID: PMC11293143.
In vivo protocol:
1: Wang P, Wood O, Choleva L, Liu H, Karakose E, Lambertini L, Pillard A, Wu V, Garcia-Ocana A, Scott DK, Kumar K, DeVita RJ, Stewart AF. Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells. bioRxiv [Preprint]. 2024 May 17:2024.05.17.594179. doi: 10.1101/2024.05.17.594179. PMID: 38798411; PMCID: PMC11118480.
2: Chen P, Qin J, Su HK, Du L, Zeng Q. Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa. BMC Infect Dis. 2024 Jul 31;24(1):760. doi: 10.1186/s12879-024-09639-9. PMID: 39085766; PMCID: PMC11293143.
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