PX-104 is a trans isomer of PX20606. PX20606, also known as PX-102 , is a FXR agonist. PX20606 induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. PX20606 demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species.
MedKoo Cat#: 529204
Name: PX-104
CAS#: 1268244-88-7 (trans isomer)
Chemical Formula: C29H22Cl3NO4
Exact Mass: 553.0614
Molecular Weight: 554.84
Elemental Analysis: C, 62.78; H, 4.00; Cl, 19.17; N, 2.52; O, 11.53
The following data is based on the product molecular weight 554.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
