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MedKoo Cat#: 414137 | Name: Etomidate HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etomidate HCl is the salt form of Etomidate, a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, and cardioversion. It was discovered at Janssen Pharmaceutica in 1964 and was introduced as an intravenous agent in 1972 in Europe and in 1983 in the United States.

Chemical Structure

Etomidate HCl
Etomidate HCl
CAS#53188-20-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 414137

Name: Etomidate HCl

CAS#: 53188-20-8 (HCl)

Chemical Formula: C14H17ClN2O2

Exact Mass: 0.0000

Molecular Weight: 280.75

Elemental Analysis: C, 59.89; H, 6.10; Cl, 12.63; N, 9.98; O, 11.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
33125-97-2 (free base) 53188-20-8 (HCl)
Synonym
Etomidate HCl; Etomidate hydrochloride; R-16659 hydrochloride; R16659 HCl; R 16659;
IUPAC/Chemical Name
ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate;hydrochloride
InChi Key
NCDXBSVHIGDPOE-RFVHGSKJSA-N
InChi Code
InChI=1S/C14H16N2O2.ClH/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3;1H/t11-;/m1./s1
SMILES Code
O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OCC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tobias JD. Etomidate in pediatric anesthesiology: Where are we now? Saudi J Anaesth. 2015 Oct-Dec;9(4):451-6. doi: 10.4103/1658-354X.159475. Review. PubMed PMID: 26543467; PubMed Central PMCID: PMC4610094. 2: Raines DE. The pharmacology of etomidate and etomidate derivatives. Int Anesthesiol Clin. 2015 Spring;53(2):63-75. doi: 10.1097/AIA.0000000000000050. Review. PubMed PMID: 25807019. 3: Bruder EA, Ball IM, Ridi S, Pickett W, Hohl C. Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. Cochrane Database Syst Rev. 2015 Jan 8;1:CD010225. doi: 10.1002/14651858.CD010225.pub2. Review. PubMed PMID: 25568981. 4: Gu WJ, Wang F, Tang L, Liu JC. Single-dose etomidate does not increase mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials and observational studies. Chest. 2015 Feb;147(2):335-46. doi: 10.1378/chest.14-1012. Review. PubMed PMID: 25255427. 5: Mosier MJ, Lasinski AM, Gamelli RL. Suspected adrenal insufficiency in critically ill burned patients: etomidate-induced or critical illness-related corticosteroid insufficiency?-A review of the literature. J Burn Care Res. 2015 Mar-Apr;36(2):272-8. doi: 10.1097/BCR.0000000000000099. Review. PubMed PMID: 25055003. 6: Erdoes G, Basciani RM, Eberle B. Etomidate--a review of robust evidence for its use in various clinical scenarios. Acta Anaesthesiol Scand. 2014 Apr;58(4):380-9. doi: 10.1111/aas.12289. Epub 2014 Mar 3. Review. PubMed PMID: 24588359. 7: van den Heuvel I, Wurmb TE, Böttiger BW, Bernhard M. Pros and cons of etomidate--more discussion than evidence? Curr Opin Anaesthesiol. 2013 Aug;26(4):404-8. doi: 10.1097/ACO.0b013e328362a84c. Review. PubMed PMID: 23743556. 8: Hunter BR, Kirschner J. In patients with severe sepsis, does a single dose of etomidate to facilitate intubation increase mortality? Ann Emerg Med. 2013 May;61(5):571-2. doi: 10.1016/j.annemergmed.2012.12.024. Epub 2013 Mar 5. Review. PubMed PMID: 23465303. 9: Budde AO, Mets B. Pro: etomidate is the ideal induction agent for a cardiac anesthetic. J Cardiothorac Vasc Anesth. 2013 Feb;27(1):180-3. doi: 10.1053/j.jvca.2012.08.024. Epub 2012 Nov 3. Review. PubMed PMID: 23127694. 10: Malhotra AK. Con: etomidate--the ideal induction agent for a cardiac anesthetic? J Cardiothorac Vasc Anesth. 2013 Feb;27(1):178-9. doi: 10.1053/j.jvca.2012.08.023. Epub 2012 Nov 3. Review. PubMed PMID: 23127693. 11: Chan CM, Mitchell AL, Shorr AF. Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis*. Crit Care Med. 2012 Nov;40(11):2945-53. doi: 10.1097/CCM.0b013e31825fec26. Review. PubMed PMID: 22971586. 12: Ray DC, McKeown DW. Etomidate for critically ill patients. Pro: yes we can use it. Eur J Anaesthesiol. 2012 Nov;29(11):506-10. doi: 10.1097/EJA.0b013e32835819b0. Review. PubMed PMID: 22907611. 13: Flynn G, Shehabi Y. Pro/con debate: Is etomidate safe in hemodynamically unstable critically ill patients? Crit Care. 2012 Jul 19;16(4):227. doi: 10.1186/cc11242. Review. PubMed PMID: 22809235; PubMed Central PMCID: PMC3580672. 14: Sneyd JR. Novel etomidate derivatives. Curr Pharm Des. 2012;18(38):6253-6. Review. PubMed PMID: 22762475. 15: Forman SA. Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate. Curr Opin Anaesthesiol. 2012 Aug;25(4):411-8. doi: 10.1097/ACO.0b013e328354feea. Review. PubMed PMID: 22614249; PubMed Central PMCID: PMC3673006. 16: Preda VA, Sen J, Karavitaki N, Grossman AB. Etomidate in the management of hypercortisolaemia in Cushing's syndrome: a review. Eur J Endocrinol. 2012 Aug;167(2):137-43. doi: 10.1530/EJE-12-0274. Epub 2012 May 10. Review. Erratum in: Eur J Endocrinol. 2013 Feb;168(2):X1. PubMed PMID: 22577107. 17: Cherfan AJ, Arabi YM, Al-Dorzi HM, Kenny LP. Advantages and disadvantages of etomidate use for intubation of patients with sepsis. Pharmacotherapy. 2012 May;32(5):475-82. doi: 10.1002/j.1875-9114.2012.01027.x. Epub 2012 Apr 9. Review. PubMed PMID: 22488264. 18: Toft P, Jensen AG. [Etomidate can not be recommended to patients with septic shock]. Ugeskr Laeger. 2011 May 16;173(20):1421-3. Review. Danish. PubMed PMID: 21586246. 19: Heyn J, Geiger C, Hinske CL, Briegel J, Weis F. Medical suppression of hypercortisolemia in Cushing's syndrome with particular consideration of etomidate. Pituitary. 2012 Jun;15(2):117-25. doi: 10.1007/s11102-011-0314-3. Review. PubMed PMID: 21556813. 20: Albert SG, Ariyan S, Rather A. The effect of etomidate on adrenal function in critical illness: a systematic review. Intensive Care Med. 2011 Jun;37(6):901-10. doi: 10.1007/s00134-011-2160-1. Epub 2011 Mar 4. Review. PubMed PMID: 21373823.