MedKoo Cat#: 558189 | Name: KC 400

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KC 400 is a mixture of polychlorinated biphenyls.

Chemical Structure

KC 400
KC 400
CAS#12737-87-0

Theoretical Analysis

MedKoo Cat#: 558189

Name: KC 400

CAS#: 12737-87-0

Chemical Formula: C12H6Cl4

Exact Mass: 289.9200

Molecular Weight: 291.98

Elemental Analysis: C, 49.36; H, 2.07; Cl, 48.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KC 400; KC400; KC-400; Kanechlor 400; Kaneclor 400;
IUPAC/Chemical Name
3,3',5,5'-tetrachloro-1,1'-biphenyl
InChi Key
UTMWFJSRHLYRPY-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H6Cl4/c13-9-1-7(2-10(14)5-9)8-3-11(15)6-12(16)4-8/h1-6H
SMILES Code
ClC1=CC(Cl)=CC(C2=CC(Cl)=CC(Cl)=C2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 291.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Honda T, Nonaka S, Murayama F, Ohgami T, Shimoyama T, Yoshida H. Effects of KC-400 (polychlorinated biphenyls) on porphyrin metabolism--liver and blood porphyrin analyses in rats treated with KC-400. J Dermatol. 1983 Jun;10(3):259-65. PubMed PMID: 6417210. 2: Nonaka S, Ohgami T, Yamashita K, Yoshida H, Murayama F. [Effects of KC-400 (polychlorinated biphenyls) on porphyrin metabolism. The influence of KC-400 and glutathione on mice fed with a feed containing a 0.1% griseofulvin]. Fukuoka Igaku Zasshi. 1985 May;76(5):215-20. Japanese. PubMed PMID: 3930371. 3: Nakayama K, Sei N, Oshima Y, Tashiro K, Shimasaki Y, Honjo T. Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126. Mar Pollut Bull. 2008;57(6-12):460-6. doi: 10.1016/j.marpolbul.2008.02.020. Epub 2008 Mar 28. PubMed PMID: 18374953. 4: Nishihara Y. Comparative study of the effects of biphenyl and Kanechlor-400 on the respiratory and energy linked activities of rat liver mitochondria. Br J Ind Med. 1985 Feb;42(2):128-32. PubMed PMID: 3918562; PubMed Central PMCID: PMC1007435. 5: Takasuga T, Kumar KS, Noma Y, Sakai S. Chemical characterization of polychlorinated biphenyls, -dibenzo-p-dioxins, and -dibenzofurans in technical Kanechlor PCB formulations in Japan. Arch Environ Contam Toxicol. 2005 Oct;49(3):385-95. Epub 2005 Sep 15. PubMed PMID: 16170452. 6: Nose K, Falandysz J, Wyrzykowska B, Orlikowska A, Noma Y. By-side PCDD/Fs in technical PCB formulations of Kanechlor series. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009 Dec;44(14):1528-37. doi: 10.1080/10934520903263348. PubMed PMID: 20183510. 7: Hori S, Obana H, Kashimoto T, Otake T, Nishimura H, Ikegami N, Kunita N, Uda H. Effect of polychlorinated biphenyls and polychlorinated quaterphenyls in Cynomolgus monkey (Macaca fascicularis). Toxicology. 1982;24(2):123-39. PubMed PMID: 6814017. 8: Furukawa K, Tomizuka N, Kamibayashi A. Metabolic breakdown of Kaneclors (polychlorobiphenyls) and their products by Acinetobacter sp. Appl Environ Microbiol. 1983 Jul;46(1):140-5. PubMed PMID: 6412627; PubMed Central PMCID: PMC239279. 9: Nakayama K, Sei N, Handoh IC, Shimasaki Y, Honjo T, Oshima Y. Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes). Mar Pollut Bull. 2011;63(5-12):366-9. doi: 10.1016/j.marpolbul.2011.01.015. Epub 2011 Feb 5. PubMed PMID: 21300381. 10: Soong DK, Ling YC. Reassessment of PCDD/DFs and Co-PCBs toxicity in contaminated rice-bran oil responsible for the disease "Yu-Cheng". Chemosphere. 1997 Mar-Apr;34(5-7):1579-86. PubMed PMID: 9134689. 11: Nishihara Y. Uncoupling action of polychlorinated biphenyls (Kanechlor-400) on oxidative phosphorylation in rat liver mitochondria. Arch Environ Contam Toxicol. 1984 Mar;13(2):225-9. PubMed PMID: 6426411. 12: Nishizumi M, Higaki Y. [Effect of PCBs on insulin sensitivity in rats]. Fukuoka Igaku Zasshi. 1995 May;86(5):241-6. Japanese. PubMed PMID: 7628815. 13: Baba D, Katayama A. Enhanced anaerobic biodegradation of polychlorinated biphenyls in burnt soil culture. J Biosci Bioeng. 2007 Jul;104(1):62-8. PubMed PMID: 17697985. 14: Takabatake E, Fujita M, Sawa Y. Combined effects of polychlorinated biphenyls and methylmercury on hepatic microsomal monooxygenases and the hepatotoxic action of bromobenzene. J Pharmacobiodyn. 1980 Sep;3(9):463-9. PubMed PMID: 6780680. 15: Hemminki K, Vineis P. Extrapolation of the evidence on teratogenicity of chemicals between humans and experimental animals: chemicals other than drugs. Teratog Carcinog Mutagen. 1985;5(4):251-318. Review. PubMed PMID: 2866606. 16: Nakagawa M, Shimokawa T, Noguchi A, Ishihara N, Kojima S. Effect of clofibrate on cholesterol metabolism in rats treated with polychlorinated biphenyls. Lipids. 1986 Feb;21(2):159-63. PubMed PMID: 3083175. 17: Shoya S, Horiuchi T, Kohanawa M. Pathological changes of experimental polychlorinated biphenyl poisoning in chickens. Natl Inst Anim Health Q (Tokyo). 1979 Summer;19(1-2):53-64. PubMed PMID: 119917. 18: Yoshihara S, Nagata K, Yoshimura H. Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital-type and 3-methylcholanthrene-type polychlorinated biphenyls in rats. J Pharmacobiodyn. 1983 Dec;6(12):954-62. PubMed PMID: 6425489. 19: Nagayama J, Kiyohara C, Handa S, Masuda Y, Kuratsune M. Effects of chlorinated dibenzofuran and dioxin on concentration and pattern of chlorobiphenyls and activity of benzo(a)pyrene hydroxylation in mice. Fukuoka Igaku Zasshi. 1985 May;76(5):175-83. PubMed PMID: 3930367. 20: Ishii K, Maeda K, Kamataki T, Kato R. Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450. Mutat Res. 1986 Jun;174(2):85-8. PubMed PMID: 3086716.