PXT-012253 | CAS#1835647-08-9 | PET radioligand

MedKoo Cat#: 145274 | Name: PXT-012253

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PXT-012253 is a carbon-11-labeled PET radioligand binding an allosteric site of mGlu4. PXT012253 displayed binding in mGlu4-expressing regions in the brain of cynomolgus monkeys. PXT012253 displayed binding in mGlu4-expressing regions in the brain of cynomolgus monkeys.

Chemical Structure

PXT-012253

CAS#1835647-08-9

Theoretical Analysis

MedKoo Cat#: 145274

Name: PXT-012253

CAS#: 1835647-08-9

Chemical Formula: C13H11ClN2OS

Exact Mass: 278.0281

Molecular Weight: 278.75

Elemental Analysis: C, 56.01; H, 3.98; Cl, 12.72; N, 10.05; O, 5.74; S, 11.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PXT-012253; PXT012253; PXT 012253;

IUPAC/Chemical Name

N-(4-chloro-3-(methylthio)phenyl)picolinamide

InChi Key

BWRWLAWESQPUSB-UHFFFAOYSA-N

InChi Code

1S/C13H11ClN2OS/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)

SMILES Code

CSC1=C(Cl)C=CC(NC(=O)C2=NC=CC=C2)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 278.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Takano A, Nag S, Jia Z, Jahan M, Forsberg A, Arakawa R, Grybäck P, Duvey G, Halldin C, Charvin D. Characterization of [11C]PXT012253 as a PET Radioligand for mGlu4 Allosteric Modulators in Nonhuman Primates. Mol Imaging Biol. 2019 Jun;21(3):500-508. doi: 10.1007/s11307-018-1257-0. PMID: 30066121. 2: Wang J, Shoup TM, Brownell AL, Zhang Z. Improved Synthesis of the Thiophenol Precursor N-(4-Chloro-3-mercaptophenyl)picolinamide for Making the mGluR4 PET Ligand. Tetrahedron. 2019 Jul 19;75(29):3917-3922. doi: 10.1016/j.tet.2019.06.010. Epub 2019 Jun 6. PMID: 32831413; PMCID: PMC7442123.