MedKoo Cat#: 532599 | Name: RU5135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU5135 is a novel convulsant amidine steroid which inhibits gamma-aminobutyric acid receptor binding.

Chemical Structure

RU5135
RU5135
CAS#78774-26-2

Theoretical Analysis

MedKoo Cat#: 532599

Name: RU5135

CAS#: 78774-26-2

Chemical Formula: C18H28N2O2

Exact Mass: 304.2151

Molecular Weight: 304.43

Elemental Analysis: C, 71.02; H, 9.27; N, 9.20; O, 10.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RU5135; RU-5135; RU 5135.
IUPAC/Chemical Name
(3aS,3bS,5aR,7S,9aS,9bS,11aS)-2-amino-7-hydroxy-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,7,8,9,9b,11-dodecahydronaphtho[2,1-e]indol-10-one
InChi Key
LLAKESJIQFAQJA-PLCDLCHKSA-N
InChi Code
InChI=1S/C18H28N2O2/c1-17-6-5-11(21)7-10(17)3-4-12-13-8-15(19)20-18(13,2)9-14(22)16(12)17/h10-13,16,21H,3-9H2,1-2H3,(H2,19,20)/t10-,11+,12+,13+,16-,17+,18+/m1/s1
SMILES Code
O=C1[C@@]2([H])[C@](CC[C@]3([H])C[C@@H](O)CC[C@@]32C)([H])[C@]4([H])CC(N)=N[C@@]4(C)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Simmonds MA, Turner JP. Antagonism of inhibitory amino acids by the steroid derivative RU5135. Br J Pharmacol. 1985 Mar;84(3):631-5. PubMed PMID: 3986429; PubMed Central PMCID: PMC1987146. 2: Olsen RW. gamma-Aminobutyric acid receptor binding antagonism by the amidine steroid RU5135. Eur J Pharmacol. 1984 Aug 17;103(3-4):333-7. PubMed PMID: 6092106.