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MedKoo Cat#: 529539 | Name: LX-2931

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LX-2931 is a sphingosine 1 phosphate lyase inhibitor potentially for the treatment of rheumatoid arthritis.

Chemical Structure

LX-2931
LX-2931
CAS#948840-25-3 (free base)

Theoretical Analysis

MedKoo Cat#: 529539

Name: LX-2931

CAS#: 948840-25-3 (free base)

Chemical Formula: C9H15N3O5

Exact Mass: 245.1012

Molecular Weight: 245.23

Elemental Analysis: C, 44.08; H, 6.17; N, 17.13; O, 32.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1078151-47-9 (dihydrate) 948840-25-3 (free base)
Synonym
LX-2931; LX-3305; LX2931; LX3305; LX 2931; LX 3305
IUPAC/Chemical Name
C/C(C1=NC(C(O)C(O)C(O)CO)=CN1)=N\O
InChi Key
AMXVYJYMZLDINS-UUILKARUSA-N
InChi Code
InChI=1S/C9H15N3O5/c1-4(12-17)9-10-2-5(11-9)7(15)8(16)6(14)3-13/h2,6-8,13-17H,3H2,1H3,(H,10,11)/b12-4+
SMILES Code
C/C(C1=NC(C(O)C(O)C(O)CO)=CN1)=N\O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 245.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Finney CA, Hawkes CA, Kain DC, Dhabangi A, Musoke C, Cserti-Gazdewich C, Oravecz T, Liles WC, Kain KC. S1P is associated with protection in human and experimental cerebral malaria. Mol Med. 2011;17(7-8):717-25. doi: 10.2119/molmed.2010.00214. PubMed PMID: 21556483; PubMed Central PMCID: PMC3146616. 2: Bagdanoff JT, Donoviel MS, Nouraldeen A, Carlsen M, Jessop TC, Tarver J, Aleem S, Dong L, Zhang H, Boteju L, Hazelwood J, Yan J, Bednarz M, Layek S, Owusu IB, Gopinathan S, Moran L, Lai Z, Kramer J, Kimball SD, Yalamanchili P, Heydorn WE, Frazier KS, Brooks B, Brown P, Wilson A, Sonnenburg WK, Main A, Carson KG, Oravecz T, Augeri DJ. Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932). J Med Chem. 2010 Dec 23;53(24):8650-62. doi: 10.1021/jm101183p. PubMed PMID: 21090716.