Synonym
AVP825; AVP-825; AVP 825; GR 43175; GR43175; GR-43175; Imitrex; Sumatriptan; Sumax
IUPAC/Chemical Name
1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-
InChi Key
KQKPFRSPSRPDEB-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
SMILES Code
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
1: Vikelis M, Spingos KC, Rapoport AM. The iontophoretic transdermal system formulation of sumatriptan as a new option in the acute treatment of migraine: a perspective. Ther Adv Neurol Disord. 2015 Jul;8(4):160-5. doi: 10.1177/1756285615585918. Review. Erratum in: Ther Adv Neurol Disord. 2015 Nov;8(6):339. PubMed PMID: 26136843; PubMed Central PMCID: PMC4480530.
2: Cady R. A novel intranasal breath-powered delivery system for sumatriptan: a review of technology and clinical application of the investigational product AVP-825 in the treatment of migraine. Expert Opin Drug Deliv. 2015;12(9):1565-77. doi: 10.1517/17425247.2015.1060959. Epub 2015 Jun 29. Review. PubMed PMID: 26119828.
3: Tepper DE. Sumatriptan iontophoretic patch for migraine. Headache. 2014 Oct;54(9):1563-4. doi: 10.1111/head.12453. Review. PubMed PMID: 25324166.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
295.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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