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MedKoo Cat#: 529522 | Name: DG026

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DG026 is a IRAP inhibitor. IRAP has been targeted with inhibitors that act as cognitive enhancers by reducing brain oxytocin degradation and enhance spine density in primary hippocampal neuron cultures. DG026 was also shown to be able to selectively downregulate IRAP-dependent cross-presentation by dendritic cells but leave ERAP1-dependent cross-presentation unaffected.

Chemical Structure

DG026
CAS#2035046-17-2

Theoretical Analysis

MedKoo Cat#: 529522

Name: DG026

CAS#: 2035046-17-2

Chemical Formula: C35H40N3O4P

Exact Mass: 597.2756

Molecular Weight: 597.70

Elemental Analysis: C, 70.33; H, 6.75; N, 7.03; O, 10.71; P, 5.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2035046-17-2 2007955-25-9
Synonym
DG026; DG-026; DG 026.
IUPAC/Chemical Name
(2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-4,4-diphenylbutyl)((R)-1-amino-3-phenylpropyl)phosphinic acid
InChi Key
FDAGDZVCWKCEEX-ITBZIINNSA-N
InChi Code
InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30?,32-,33+/m0/s1
SMILES Code
N[C@@H](CCC1=CC=CC=C1)P(CC(CC(C2=CC=CC=C2)C3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N)=O)=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Insulin-regulated aminopeptidase (IRAP, also known as leucylcystinyl aminopeptidase, placental leucine aminopeptidase, and oxytocinase, EC 3.4.11.3) is a transmembrane zinc aminopeptidase that is tasked with several biological functions including the generation of antigenic peptides for crosspresentation, regulation of trafficking of glucose transporter type 4, control of oxytocin levels in pregnancy, and regulation of brain oxytocin and vasopressin levels.

Preparing Stock Solutions

The following data is based on the product molecular weight 597.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity Anastasia Mpakali, Emmanuel Saridakis, Karl Harlos, Yuguang Zhao, Paraskevi Kokkala, Dimitris Georgiadis, Petros Giastas, Athanasios Papakyriakou, and Efstratios Stratikos Publication Date (Web): March 22, 2017 (Article) DOI: 10.1021/acs.jmedchem.6b01890