MedKoo Cat#: 581660 | Name: Diethylcarbamazine N-oxide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylcarbamazine N-Oxide is a metabolite of Diethylcarbamazine (D443910) in mammals. Diethylcarbamazine N-Oxide shows more antifilarial activity than its parent compound.

Chemical Structure

Diethylcarbamazine N-oxide
CAS#34812-73-2

Theoretical Analysis

MedKoo Cat#: 581660

Name: Diethylcarbamazine N-oxide

CAS#: 34812-73-2

Chemical Formula: C10H21N3O2

Exact Mass: 215.1634

Molecular Weight: 215.30

Elemental Analysis: C, 55.79; H, 9.83; N, 19.52; O, 14.86

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Synonym
Diethylcarbamazine N-oxide; Diethylcarbamazine-N-oxide; Dec N-oxide.
IUPAC/Chemical Name
1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, 4-oxide
InChi Key
KAJAFGMERLXELG-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H21N3O2/c1-4-11(5-2)10(14)12-6-8-13(3,15)9-7-12/h4-9H2,1-3H3
SMILES Code
O=C(N1CC[N+](C)([O-])CC1)N(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 215.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Edwards G, Ward SA, Breckenridge AM, Orme ML. Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine. Xenobiotica. 1981 Apr;11(4):281-4. PubMed PMID: 7303719. 2: Chandrasekaran B, Ghirnikar SN, Harinath BC. Effect of diethylcarbamazine & diethylcarbamazine-N-oxide on microfilariae in vitro in the presence of immune sera & leukocytes. Indian J Exp Biol. 1980 Oct;18(10):1179-80. PubMed PMID: 7216270. 3: Chandrasekaran B, Harinath BC. Isolation, characterization and estimation of diethylcarbamazine-N-oxide from human urine. Indian J Med Res. 1979 Aug;70:305-8. PubMed PMID: 521100.