MedKoo Cat#: 407365 | Name: Fagaronine chloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fagaronine chloride is a potent Topoisomerases I inhibitor.

Chemical Structure

Fagaronine chloride
Fagaronine chloride
CAS#52259-64-0 (chloride)

Theoretical Analysis

MedKoo Cat#: 407365

Name: Fagaronine chloride

CAS#: 52259-64-0 (chloride)

Chemical Formula: C21H20ClNO4

Exact Mass:

Molecular Weight: 385.84

Elemental Analysis: C, 65.37; H, 5.22; Cl, 9.19; N, 3.63; O, 16.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Fagaronine chloride; NSC 157995; NSC-157995; NSC157995.
IUPAC/Chemical Name
2-Hydroxy-3,8,9-trimethoxy-5-methylbenzo(c)phenanthridinium chloride
InChi Key
VVEPUJCLNRDIEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19NO4.ClH/c1-22-11-13-8-19(25-3)20(26-4)9-15(13)14-6-5-12-7-17(23)18(24-2)10-16(12)21(14)22;/h5-11H,1-4H3;1H
SMILES Code
C[N+]1=CC2=CC(OC)=C(OC)C=C2C3=C1C4=CC(OC)=C(O)C=C4C=C3.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pérez-Chiesa Y, Narváez Z. Evaluation of genotoxicity of the indenoisoquinoline analogues of fagaronine and nitidine in Drosophila melanogaster. Mutat Res. 1993 Apr;301(4):207-12. PubMed PMID: 7680753. 2: Cushman M, Mohan P. Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride. J Med Chem. 1985 Aug;28(8):1031-6. PubMed PMID: 4020826. 3: Janin YL, Croisy A, Riou JF, Bisagni E. Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives. J Med Chem. 1993 Nov 12;36(23):3686-92. PubMed PMID: 8246238. 4: Tan GT, Lee S, Lee IS, Chen J, Leitner P, Besterman JM, Kinghorn AD, Pezzuto JM. Natural-product inhibitors of human DNA ligase I. Biochem J. 1996 Mar 15;314 ( Pt 3):993-1000. PubMed PMID: 8615799; PubMed Central PMCID: PMC1217154. 5: Sethi VS. Base specificity in the inhibition of oncornavirus reverse transcriptase and cellular nucleic acid polymerases by antitumor drugs. Ann N Y Acad Sci. 1977 Mar 4;284:508-24. PubMed PMID: 81641. 6: Sethi VS. Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids. Cancer Res. 1976 Jul;36(7 PT 1):2390-5. PubMed PMID: 58719.