FX1 is an inhibitor of the B cell lymphoma 6 (BCL6). FX1 has 10-fold greater potency than endogenous corepressors and binds an essential region of the BCL6 lateral groove. FX1 disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, and mimicked the phenotype of mice engineered to express BCL6 with corepressor binding site mutations. Low doses of FX1 induced regression of established tumors in mice bearing DLBCL xenografts. Furthermore, FX1 suppressed ABC-DLBCL cells in vitro and in vivo, as well as primary human ABC-DLBCL specimens ex vivo.
MedKoo Cat#: 407501
Name: FX1
CAS#: 1426138-42-2
Chemical Formula: C14H9ClN2O4S2
Exact Mass: 367.9690
Molecular Weight: 368.81
Elemental Analysis: C, 45.59; H, 2.46; Cl, 9.61; N, 7.60; O, 17.35; S, 17.39
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.2 | 65.67 | |
| DMF | 30.0 | 81.34 |
The following data is based on the product molecular weight 368.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
