MedKoo Cat#: 532960 | Name: WAY170523
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

WAY170523 is a selective and potent inhibitor of MMP-13(IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). MMPs (matrix metalloproteinases) are commonly known to be involved in the degradation of various extracellular matrix proteins.

Chemical Structure

WAY170523
WAY170523
CAS#307002-73-9

Theoretical Analysis

MedKoo Cat#: 532960

Name: WAY170523

CAS#: 307002-73-9

Chemical Formula: C33H31N3O7S

Exact Mass: 613.1883

Molecular Weight: 613.69

Elemental Analysis: C, 64.59; H, 5.09; N, 6.85; O, 18.25; S, 5.22

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
WAY170523; WAY-170523; WAY 170523
IUPAC/Chemical Name
N-[2-(4-{benzyl[2-(hydroxycarbamoyl)-4,6-dimethylphenyl]sulfamoyl}phenoxy)ethyl]-1-benzofuran-2-carboxamide
InChi Key
FARMEEAGJWMFSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H31N3O7S/c1-22-18-23(2)31(28(19-22)32(37)35-39)36(21-24-8-4-3-5-9-24)44(40,41)27-14-12-26(13-15-27)42-17-16-34-33(38)30-20-25-10-6-7-11-29(25)43-30/h3-15,18-20,39H,16-17,21H2,1-2H3,(H,34,38)(H,35,37)
SMILES Code
O=C(C(O1)=CC2=C1C=CC=C2)NCCOC3=CC=C(S(=O)(N(CC4=CC=CC=C4)C5=C(C)C=C(C)C=C5C(NO)=O)=O)C=C3
Appearance
White to beige solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 613.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Dixon, A. E., Jaffre, F., Mackman, N., & Blaxall, B. C. (2014). Inhibition Of Matrix Metalloproteinase-13 Dependent Protease-activated Receptor-1 Activation Attenuates Fibrotic Signaling. Circulation Research, 115(suppl_1), A311-A311. Toriseva, M., Fagerlund, K., Mattsson, J., Kähkönen, T. E., Ahonen, I., Åkerfelt, M., ... & Mäki-Jouppila, J. H. (2018). Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Research, 78(13_Supplement), 1158-1158. Chen, J. M., Nelson, F. C., Levin, J. I., Mobilio, D., Moy, F. J., Nilakantan, R., ... & Powers, R. (2000). Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. Journal of the American Chemical Society, 122(40), 9648-9654.Yu, H., Fellows, A., Foote, K., Yang, Z., Figg, N., Littlewood, T., & Bennett, M. (2018). Yu, H., Fellows, A., Foote, K., Yang, Z., Figg, N., Littlewood, T., & Bennett, M. (2018). FOXO3a (forkhead transcription factor O subfamily member 3a) links vascular smooth muscle cell apoptosis, matrix breakdown, atherosclerosis, and vascular remodeling through a novel pathway involving MMP13 (matrix metalloproteinase 13). Arteriosclerosis, thrombosis, and vascular biology, 38(3), 555-565.