Synonym
Sch 40853; Sch40853; Sch-40853.
IUPAC/Chemical Name
11-Chloro-6,6a,7,8,9,13b-hexahydro-5H-benzo(d)naphth(2,1-b)azepine-12-ol
SMILES Code
OC1=C(Cl)C=C2C(C3C(CCC4=C3C=CC=C4)NCC2)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
299.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lin CC, Kim HK, Parker D. Sensitive high-performance liquid chromatographic method for the determination of a benzonaphthazepine antipsychotic agent, SCH 39166, and its active metabolite, SCH 40853, in human plasma and its cross-validation with a gas chromatographic method. J Chromatogr B Biomed Appl. 1996 Jul 12;682(2):309-13. PubMed PMID: 8844424.
2: Tedford CE, Coffin VL, Ruperto V, Cohen M, McQuade RD, Johnson R, Kim HK, Lin CC. Determination of plasma and brain concentrations of SCH 39166 and their correlation to conditioned avoidance behavior in rats. Psychopharmacology (Berl). 1993;113(2):199-204. PubMed PMID: 7855181.
3: Halldin C, Farde L, Barnett A, Sedvall G. Synthesis of carbon-11 labelled SCH 39166, a new selective dopamine D-1 receptor ligand, and preliminary PET investigations. Int J Rad Appl Instrum A. 1991;42(5):451-5. PubMed PMID: 1646191.
