Nedocromil sodium trihydrate | CAS# 111681-48-2 | Biochemical

MedKoo Cat#: 578050 | Name: Nedocromil sodium trihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nedocromil sodium trihydrate is a pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with Asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.

Chemical Structure

Nedocromil sodium trihydrate

CAS#111681-48-2

Theoretical Analysis

MedKoo Cat#: 578050

Name: Nedocromil sodium trihydrate

CAS#: 111681-48-2

Chemical Formula: C19H21NNa2O10

Exact Mass: 469.0961

Molecular Weight: 469.35

Elemental Analysis: C, 48.62; H, 4.51; N, 2.98; Na, 9.80; O, 34.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Nedocromil sodium trihydrate

IUPAC/Chemical Name

sodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylate trihydrate

InChi Key

QRUGNCIIESVHAR-UHFFFAOYSA-L

InChi Code

InChI=1S/C19H17NO7.2Na.3H2O/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;;;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;;3*1H2/q;2*+1;;;/p-2

SMILES Code

O.O.O.[Na+].[Na+].CCCc1c2OC(=CC(=O)c2cc3C(=O)C=C(N(CC)c13)C(=O)[O-])C(=O)[O-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 469.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sridhar AV, McKean M. Nedocromil sodium for chronic asthma in children. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD004108. Review. PubMed PMID: 16856028. 2: Dudley T, Parker S, Baldwin R. Clinical inquiries. Is nedocromil effective in preventing asthmatic attacks in patients with asthma? J Fam Pract. 2004 Nov;53(11):927-8. Review. PubMed PMID: 15527735. 3: Mihălţan F, Ulmeanu R, Panghea P. [The therapeutic position of nedocromil sodium (Tilade) in the treatment of bronchial asthma]. Pneumologia. 1999 Oct-Dec;48(4):309-12. Review. Romanian. PubMed PMID: 10856993. 4: Kelly KD, Spooner CH, Rowe BH. Nedocromil sodium versus cromoglycate for the pre-treatment of exercise induced bronchoconstriction in asthma. Cochrane Database Syst Rev. 2000;(2):CD002169. Review. PubMed PMID: 10796684. 5: Spooner CH, Saunders LD, Rowe BH. Nedocromil sodium for preventing exercise-induced bronchoconstriction. Cochrane Database Syst Rev. 2000;(2):CD001183. Review. Update in: Cochrane Database Syst Rev. 2002;(1):CD001183. PubMed PMID: 10796616.