Synonym
8Aminoinosine, 8aminoinosine, NSC109320
IUPAC/Chemical Name
(2R,3R,4S,5R)-2-(8-Amino-6-hydroxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChi Key
OBCXRIVPFSZZSN-UUOKFMHZSA-N
InChi Code
InChI=1S/C10H13N5O5/c11-10-14-4-7(12-2-13-8(4)19)15(10)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H2,11,14)(H,12,13,19)/t3-,5-,6-,9-/m1/s1
SMILES Code
O[C@H]1[C@H](N2C(N)=NC3=C(O)N=CN=C23)O[C@H](CO)[C@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
283.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jackson EK, Menshikova EV, Ritov VB, Mi Z, Birder LA. 8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity. J Pharmacol Exp Ther. 2022 Aug;382(2):135-148. doi: 10.1124/jpet.122.001221. Epub 2022 May 24. PMID: 35609923.
2: Rabuffetti M, Rinaldi F, Lo Bianco A, Speranza G, Ubiali D, de Moraes MC, Rodrigues Pereira da Silva LC, Massolini G, Calleri E, Lavecchia A. Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay. ChemMedChem. 2021 Apr 20;16(8):1325-1334. doi: 10.1002/cmdc.202000874. Epub 2021 Feb 17. PMID: 33405358.
3: Secrist JA 3rd, Bennett LL Jr, Allan PW, Rose LM, Chang CH, Montgomery JA. Synthesis and biochemical properties of 8-amino-6-fluoro-9-beta-D- ribofuranosyl-9H-purine. J Med Chem. 1986 Oct;29(10):2069-74. doi: 10.1021/jm00160a046. PMID: 3489838.
