MedKoo Cat#: 208049 | Name: CPT-Se4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CPT-Se4 is a Camptothecin Prodrug with Improved Cytotoxicity to Cancer Cells. CPT-Se4 wase identified to show improved potency in killing cancer cells and inhibiting tumor growth in vivo.

Chemical Structure

CPT-Se4
CPT-Se4
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208049

Name: CPT-Se4

CAS#: N/A

Chemical Formula: C25H24N2O7Se2

Exact Mass: 623.9914

Molecular Weight: 622.39

Elemental Analysis: C, 48.25; H, 3.89; N, 4.50; O, 17.99; Se, 25.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CPT-Se4; CPT Se4; CPTSe4; CPT-Se 4
IUPAC/Chemical Name
(S)-2-(l1-selanyl)ethyl (4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) carbonate compound with 2-(l1-selanyl)ethan-1-ol (1:1)
InChi Key
TZJJWMQMIRGDPO-BQAIUKQQSA-N
InChi Code
InChI=1S/C23H19N2O6Se.C2H5OSe/c1-2-23(31-22(28)29-7-8-32)16-10-18-19-14(9-13-5-3-4-6-17(13)24-19)11-25(18)20(26)15(16)12-30-21(23)27;3-1-2-4/h3-6,9-10H,2,7-8,11-12H2,1H3;3H,1-2H2/t23-;/m0./s1
SMILES Code
O=C1C2=C([C@@](OC(OCC[Se])=O)(CC)C(OC2)=O)C=C(N1C3)C4=C3C=C5C(C=CC=C5)=N4.[Se]CCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 622.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhao J, Wang Z, Zhong M, Xu Q, Li X, Chang B, Fang J. Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells. J Med Chem. 2021 Dec 23;64(24):17979-17991. doi: 10.1021/acs.jmedchem.1c01362. Epub 2021 Dec 1. PMID: 34852457.