Synonym
Divaplon; RU 32698; RU-32698; RU32698.
IUPAC/Chemical Name
(6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)(phenyl)methanone
InChi Key
NRJVHCSYLGLURI-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3
SMILES Code
O=C(C1=CN2C(C)=C(CC)C(OC)=NC2=N1)C3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
295.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pellón R, Ruíz A, Lamas E, Rodríguez C. Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats. Behav Pharmacol. 2007 Feb;18(1):81-7. PubMed PMID: 17218801.
2: Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol. 2006 Feb;69(2):640-9. PubMed PMID: 16272224.
3: Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochem Pharmacol. 2004 Oct 15;68(8):1621-9. PubMed PMID: 15451405.
4: Sanger DJ, Joly D, Perrault G. Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice. Psychopharmacology (Berl). 1995 Sep;121(1):104-8. PubMed PMID: 8539334.
5: Sanger DJ. Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue. Behav Pharmacol. 1995 Mar;6(2):116-126. PubMed PMID: 11224318.
6: Knoflach F, Drescher U, Scheurer L, Malherbe P, Mohler H. Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes. J Pharmacol Exp Ther. 1993 Jul;266(1):385-91. PubMed PMID: 8392559.
7: Tully WR, Gardner CR, Gillespie RJ, Westwood R. 2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors. J Med Chem. 1991 Jul;34(7):2060-7. PubMed PMID: 1648620.
8: Feely M, Boyland P, Picardo A, Cox A, Gent JP. Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812. Eur J Pharmacol. 1989 May 19;164(2):377-80. PubMed PMID: 2759183.
