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MedKoo Cat#: 525806 | Name: PPQ-581

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPQ-581 is a novel anti-influenza agent, interrupting the crucial RNP trafficking, resulting in influenza replication inhibition, preventing virus-induced cytopathic effects.

Chemical Structure

PPQ-581
PPQ-581
CAS#950381-32-5

Theoretical Analysis

MedKoo Cat#: 525806

Name: PPQ-581

CAS#: 950381-32-5

Chemical Formula: C25H24FN3O3

Exact Mass: 433.1802

Molecular Weight: 433.48

Elemental Analysis: C, 69.27; H, 5.58; F, 4.38; N, 9.69; O, 11.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PPQ-581
IUPAC/Chemical Name
5-(2-Fluoro-phenyl)-2,4,8,8-tetramethyl-9-phenyl-4,5,7,8-tetrahydro-6-oxa-2,4,8a-triaza-fluorene-1,3-dione
InChi Key
FTIYTQDSSDROKM-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H24FN3O3/c1-25(2)14-32-22(16-12-8-9-13-17(16)26)21-20-18(23(30)28(4)24(31)27(20)3)19(29(21)25)15-10-6-5-7-11-15/h5-13,22H,14H2,1-4H3
SMILES Code
O=C(N1C)C2=C(C3=CC=CC=C3)N4C(C)(C)COC(C5=CC=CC=C5F)C4=C2N(C)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lin MI, Su BH, Lee CH, Wang ST, Wu WC, Dangate P, Wang SY, Huang WI, Cheng TJ, Lin OA, Cheng YS, Tseng YJ, Sun CM. Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1. Eur J Med Chem. 2015 Sep 18;102:477-86. doi: 10.1016/j.ejmech.2015.08.016. Epub 2015 Aug 13. PubMed PMID: 26310893.