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MedKoo Cat#: 208565 | Name: PPPA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPPA comes from from Pseudomonas aeruginosa, and is a key regulatory component of type VI secretion systems

Chemical Structure

PPPA
PPPA
CAS#48166-95-6

Theoretical Analysis

MedKoo Cat#: 208565

Name: PPPA

CAS#: 48166-95-6

Chemical Formula: C15H17NO

Exact Mass: 227.1310

Molecular Weight: 227.31

Elemental Analysis: C, 79.26; H, 7.54; N, 6.16; O, 7.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Benzenepropanamine, gamma-phenoxy, gamma-Phenoxybenzenepropanamine, PPPA, UNII-EE55YAQ6HN
IUPAC/Chemical Name
(3-Amino-1-phenoxypropyl)benzene
InChi Key
XYWLZHPZECQHMB-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17NO/c16-12-11-15(13-7-3-1-4-8-13)17-14-9-5-2-6-10-14/h1-10,15H,11-12,16H2
SMILES Code
NCCC(C1=CC=CC=C1)OC2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 227.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang Z, Wang X, Xu W, Zhou M, Zhang Y, Ma Y, Wang Q. Phosphorylation of PppA at threonine 253 controls T6SS2 expression and bacterial killing capacity in the marine pathogen Vibrio alginolyticus. Microbiol Res. 2018 Apr;209:70-78. doi: 10.1016/j.micres.2018.02.004. Epub 2018 Feb 22. PMID: 29580623. 2: Wu Y, Gong J, Liu S, Li D, Wu Y, Zhang X, Ren Y, Xu S, Sun J, Wang T, Lin Q, Liu L. Crystal structure of PppA from Pseudomonas aeruginosa, a key regulatory component of type VI secretion systems. Biochem Biophys Res Commun. 2019 Aug 13;516(1):196-201. doi: 10.1016/j.bbrc.2019.06.020. Epub 2019 Jun 14. PMID: 31208722. 3: Green BA, Zhang Y, Masi AW, Barniak V, Wetherell M, Smith RP, Reddy MS, Zhu D. PppA, a surface-exposed protein of Streptococcus pneumoniae, elicits cross- reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model. Infect Immun. 2005 Feb;73(2):981-9. doi: 10.1128/IAI.73.2.981-989.2005. PMID: 15664941; PMCID: PMC547003. 4: Sheng L, Lv Y, Liu Q, Wang Q, Zhang Y. Connecting type VI secretion, quorum sensing, and c-di-GMP production in fish pathogen Vibrio alginolyticus through phosphatase PppA. Vet Microbiol. 2013 Mar 23;162(2-4):652-662. doi: 10.1016/j.vetmic.2012.09.009. Epub 2012 Sep 14. PMID: 23021863. 5: Hovanessian AG, Wood JN. Anticellular and antiviral effects of pppA(2'p5'A)n. Virology. 1980 Feb;101(1):81-90. doi: 10.1016/0042-6822(80)90485-7. PMID: 6243832. 6: Kaiser KP, Geuting B, Grossmann K, Vester E, Lösse B, Antar MA, Machulla HJ, Feinendegen LE. Tracer kinetics of 15-(ortho-123/131I-phenyl)-pentadecanoic acid (oPPA) and 15-(para-123/131I-phenyl)-pentadecanoic acid (pPPA) in animals and man. J Nucl Med. 1990 Oct;31(10):1608-16. PMID: 2213181. 7: Minks MA, Benvin S, Baglioni C. Mechanism of pppA(2'p5'A)n2'p5'AOH synthesis in extracts of interferon-treated HeLa cells. J Biol Chem. 1980 Jun 10;255(11):5031-5. PMID: 6154699. 8: Yang J, Baldi DL, Tauschek M, Strugnell RA, Robins-Browne RM. Transcriptional regulation of the yghJ-pppA-yghG-gspCDEFGHIJKLM cluster, encoding the type II secretion pathway in enterotoxigenic Escherichia coli. J Bacteriol. 2007 Jan;189(1):142-50. doi: 10.1128/JB.01115-06. Epub 2006 Nov 3. PMID: 17085567; PMCID: PMC1797218. 9: Villena J, Medina M, Raya R, Alvarez S. Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection. Can J Microbiol. 2008 Oct;54(10):845-53. doi: 10.1139/w08-077. PMID: 18923553. 10: Vintiñi E, Villena J, Alvarez S, Medina M. Administration of a probiotic associated with nasal vaccination with inactivated Lactococcus lactis-PppA induces effective protection against pneumoccocal infection in young mice. Clin Exp Immunol. 2010 Mar;159(3):351-62. doi: 10.1111/j.1365-2249.2009.04056.x. Epub 2009 Dec 4. PMID: 20002449; PMCID: PMC2819501.