Synonym
Etamiphylline Camsilate; R-3588; R 3588; R3588; Milliphylline; Soluphyline; Parephyllin;
IUPAC/Chemical Name
7-(2-(diethylamino)ethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione ((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate
InChi Key
KVZYKZBYZVKXNI-FHIDHQGESA-N
InChi Code
InChI=1S/C13H21N5O2.C10H16O4S/c1-5-17(6-2)7-8-18-9-14-11-10(18)12(19)16(4)13(20)15(11)3;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h9H,5-8H2,1-4H3;7H,3-6H2,1-2H3,(H,12,13,14)/t;7?,10-/m.1/s1
SMILES Code
CC1(C)[C@@]2(CS(=O)(O)=O)CCC1CC2=O.O=C(N3C)N(C)C4=C(N(CCN(CC)CC)C=N4)C3=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS#
314-35-2 (Etamiphylline)
19326-29-5 (Etamiphylline Camsilate)
Preparing Stock Solutions
The following data is based on the
product
molecular weight
511.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wieder ME, Brown PR, Grainger L, Teale P. Identification of etamiphylline and metabolites in equine plasma and urine by accurate mass and liquid chromatography/tandem mass spectrometry. Drug Test Anal. 2010 Jun;2(6):271-7. doi: 10.1002/dta.133. PubMed PMID: 20564606.
2: Fennell C. Nitrite toxicity in cattle and etamiphylline camsylate. Vet Rec. 1979 Jan 6;104(1):22. PubMed PMID: 433104.
3: Dumasia MC, Teale P. N-deethylation and N-oxidation of etamiphylline: identification of etamiphylline-N-oxide in greyhound urine by high performance liquid chromatography-mass spectrometry. J Pharm Biomed Anal. 2005 Jan 4;36(5):1085-91. PubMed PMID: 15620536.
4: Elghazali M, Wasfi IA, Al Katheeri NA, Hadi AA, Hussein MM. The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration. J Vet Pharmacol Ther. 2002 Feb;25(1):43-8. PubMed PMID: 11874526.
5: Gleeson M, Haigh AL, Molony V, Anderson LS. Ventilatory and cardiovascular responses of the unanaesthetized chicken, Gallus domesticus, to the respiratory stimulants etamiphylline and almitrine. Comp Biochem Physiol C. 1985;81(2):367-74. PubMed PMID: 2861956.
6: Addis GJ. Absence of bronchodilatory effect from etamiphylline. Lancet. 1984 May 12;1(8385):1083. PubMed PMID: 6144017.
7: Vazquez C, Labayru T, Rodriguez-Soriano J. Poor bronchodilator effect of oral etamiphylline in asthmatic children. Lancet. 1984 Apr 21;1(8382):914. PubMed PMID: 6143224.
8: Vázquez C, Labayru MT. [Comparative study of the effect of a single oral dose of theophylline and etamiphyllin in children with asthma]. An Esp Pediatr. 1984 Nov 30;21(8):739-46. Spanish. PubMed PMID: 6529027.
9: Atwell RB. The use of alpha blockade in the treatment of congestive heart failure associated with dirofilariasis and mitral valvular incompetence. Vet Rec. 1979 Feb 10;104(6):114-6. PubMed PMID: 452344.
10: Perkins MN, Stone TW. Aminophylline and theophylline derivatives as antagonists of neuronal depression by adenosine: a microiontophoretic study. Arch Int Pharmacodyn Ther. 1980 Aug;246(2):205-14. PubMed PMID: 7436627.
11: Burcet Darde J. [Accidental epileptic crises. Importance of drugs and the genetic factor in their presentation]. Neurologia. 1992 Oct;7(8):238-9. Spanish. PubMed PMID: 1449845.
12: Brown M. An overdose of dog's heart tablets. Hum Exp Toxicol. 1990 May;9(3):201. PubMed PMID: 2375890.
13: Torres A, Rovira J, Zapatero D, Vilageliu J, Ribalta M, Bruseghini L. [Serum levels and urinary and fecal excretion of ethamicylin HCI (solucylin). Oral and intravenous administration (author's transl)]. Arch Farmacol Toxicol. 1980 Dec;6(3):237-46. Spanish. PubMed PMID: 7305455.
14: Scopinaro F, Cicala M, Vignoni A, Corazziari E. [Effect of spasmodil complex on bile flow. Double-blind controlled study]. Minerva Dietol Gastroenterol. 1988 Jan-Mar;34(1):39-41. Italian. PubMed PMID: 3386863.
