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MedKoo Cat#: 413274 | Name: Etamiphyllin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etamiphyllin is a xanthine intended for use as an anti-asthma agent.

Chemical Structure

Etamiphyllin
Etamiphyllin
CAS#314-35-2 (free base)

Theoretical Analysis

MedKoo Cat#: 413274

Name: Etamiphyllin

CAS#: 314-35-2 (free base)

Chemical Formula: C13H21N5O2

Exact Mass: 279.1695

Molecular Weight: 279.34

Elemental Analysis: C, 55.90; H, 7.58; N, 25.07; O, 11.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
17140-68-0 (HCl) 19326-29-5 (camsilate) 314-35-2 (free base)
Synonym
Etamiphyllin; R3588; R 3588; R-3588
IUPAC/Chemical Name
1H-Purine-2,6-dione, 7-(2-(diethylamino)ethyl)-3,7-dihydro-1,3-dimethyl- (9CI)
InChi Key
AWKLBIOQCIORSB-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21N5O2/c1-5-17(6-2)7-8-18-9-14-11-10(18)12(19)16(4)13(20)15(11)3/h9H,5-8H2,1-4H3
SMILES Code
O=C(N1C)N(C)C2=C(N(CCN(CC)CC)C=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 279.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vázquez C, Labayru MT. Un estudio comparativo del efecto de una dosis oral única de teofilina y de etamifilina en niños con asma [Comparative study of the effect of a single oral dose of theophylline and etamiphyllin in children with asthma]. An Esp Pediatr. 1984 Nov 30;21(8):739-46. Spanish. PMID: 6529027. 2: Turner T. Recent studies with etamiphyllin camsylate. Vet Rec. 1974 Jun 15;94(24):560-1. doi: 10.1136/vr.94.24.560. PMID: 4372778. 3: Wieder ME, Brown PR, Grainger L, Teale P. Identification of etamiphylline and metabolites in equine plasma and urine by accurate mass and liquid chromatography/tandem mass spectrometry. Drug Test Anal. 2010 Jun;2(6):271-7. doi: 10.1002/dta.133. PMID: 20564606. 4: Elghazali M, Wasfi IA, Al Katheeri NA, Hadi AA, Hussein MM. The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration. J Vet Pharmacol Ther. 2002 Feb;25(1):43-8. doi: 10.1046/j.1365-2885.2002.00383.x. PMID: 11874526. 5: Addis GJ. Absence of bronchodilatory effect from etamiphylline. Lancet. 1984 May 12;1(8385):1083. doi: 10.1016/s0140-6736(84)91497-1. PMID: 6144017. 6: Dumasia MC, Teale P. N-deethylation and N-oxidation of etamiphylline: identification of etamiphylline-N-oxide in greyhound urine by high performance liquid chromatography-mass spectrometry. J Pharm Biomed Anal. 2005 Jan 4;36(5):1085-91. doi: 10.1016/j.jpba.2004.09.005. PMID: 15620536. 7: Vazquez C, Labayru T, Rodriguez-Soriano J. Poor bronchodilator effect of oral etamiphylline in asthmatic children. Lancet. 1984 Apr 21;1(8382):914. doi: 10.1016/s0140-6736(84)91380-1. PMID: 6143224. 8: Brown M. An overdose of dog's heart tablets. Hum Exp Toxicol. 1990 May;9(3):201. doi: 10.1177/096032719000900316. PMID: 2375890. 9: Torres A, Rovira J, Zapatero D, Vilageliu J, Ribalta M, Bruseghini L. Niveles séricos y excreción urinaria y fecal de la etamifilina HCl (solufilina). Administración oral e intravenosa [Serum levels and urinary and fecal excretion of ethamicylin HCI (solucylin). Oral and intravenous administration (author's transl)]. Arch Farmacol Toxicol. 1980 Dec;6(3):237-46. Spanish. PMID: 7305455. 10: Fennell C. Nitrite toxicity in cattle and etamiphylline camsylate. Vet Rec. 1979 Jan 6;104(1):22. doi: 10.1136/vr.104.1.22. PMID: 433104.