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MedKoo Cat#: 574188 | Name: TAN 1364B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682. TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B, but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.

Chemical Structure

TAN 1364B
TAN 1364B
CAS#154639-24-4

Theoretical Analysis

MedKoo Cat#: 574188

Name: TAN 1364B

CAS#: 154639-24-4

Chemical Formula: C21H36O5

Exact Mass: 368.2563

Molecular Weight: 368.51

Elemental Analysis: C, 68.45; H, 9.85; O, 21.71

Price and Availability

Size Price Availability Quantity
2mg USD 1,300.00
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Related CAS #
No Data
Synonym
RK-682 (rac-1), TAN 1364B
IUPAC/Chemical Name
4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone
InChi Key
KZTSLHQKWLYYAC-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3
SMILES Code
O=C1C(C(CCCCCCCCCCCCCCC)=O)=C(O)C(CO)O1
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Carneiro, V.M.T., Trivella, D.B.B., Scorsato, V., et al. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. Eur. J. Med. Chem. 97, 42-54 (2015).