MedKoo Cat#: 525544 | Name: LY 326325

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 326325 is a competitive AMPA receptor antagonist.

Chemical Structure

LY 326325
LY 326325
CAS#177314-99-7

Theoretical Analysis

MedKoo Cat#: 525544

Name: LY 326325

CAS#: 177314-99-7

Chemical Formula: C13H21N5O2

Exact Mass: 279.1695

Molecular Weight: 279.34

Elemental Analysis: C, 55.90; H, 7.58; N, 25.07; O, 11.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY 326325; LY326325; LY326325.
IUPAC/Chemical Name
3-Isoquinolinecarboxylic acid, decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-, (3alpha,4abeta,6alpha,8abeta)-
InChi Key
ZXFRFPSZAKNPQQ-VLEAKVRGSA-N
InChi Code
InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11-/m0/s1
SMILES Code
O=C([C@H]1NC[C@@]2([H])CC[C@@H](CCC3=NN=NN3)C[C@@]2([H])C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 279.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Day M, Langston RF. Post-training N-methyl-D-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze. Neuroscience. 2006;137(1):19-28. Epub 2005 Nov 10. PubMed PMID: 16289349. 2: Micheau J, Riedel G, Roloff Ev, Inglis J, Morris RG. Reversible hippocampal inactivation partially dissociates how and where to search in the water maze. Behav Neurosci. 2004 Oct;118(5):1022-32. PubMed PMID: 15506884. 3: Kundrotiene J, Wägner A, Liljequist S. Fluoro-Jade and TUNEL staining as useful tools to identify ischemic brain damage following moderate extradural compression of sensorimotor cortex. Acta Neurobiol Exp (Wars). 2004;64(2):153-62. PubMed PMID: 15366248. 4: Kundrotiené J, Wägner A, Liljequist S. Extradural compression of sensorimotor cortex: a useful model for studies on ischemic brain damage and neuroprotection. J Neurotrauma. 2002 Jan;19(1):69-84. PubMed PMID: 11852980. 5: Svensson TH, Mathé JM. Atypical antipsychotic-like effect of AMPA receptor antagonists in the rat. Amino Acids. 2000;19(1):221-6. PubMed PMID: 11026492. 6: Mathé JM, Fagerquist MV, Svensson TH. Antipsychotic-like effect of the AMPA receptor antagonist LY326325 as indicated by suppression of conditioned avoidance response in the rat. J Neural Transm (Vienna). 1999;106(9-10):1003-9. PubMed PMID: 10599880. 7: Kotlinska J, Liljequist S. The putative AMPA receptor antagonist, LY326325, produces anxiolytic-like effects without altering locomotor activity in rats. Pharmacol Biochem Behav. 1998 May;60(1):119-24. PubMed PMID: 9610933. 8: Vanover KE. Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice. Psychopharmacology (Berl). 1998 Mar;136(2):123-31. PubMed PMID: 9551768. 9: Liljequist S, Cebers G, Kalda A. Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons. Biochem Pharmacol. 1995 Nov 27;50(11):1761-74. PubMed PMID: 8615854. 10: Karcz-Kubicha M, Liljequist S. Effects of post-ethanol administration of NMDA and non-NMDA receptor antagonists on the development of ethanol tolerance in C57B1 mice. Psychopharmacology (Berl). 1995 Jul;120(1):49-56. PubMed PMID: 7480535. 11: Karcz-Kubicha M, Liljequist S. Evidence for an anxiogenic action of AMPA receptor antagonists in the plus-maze test. Eur J Pharmacol. 1995 Jun 12;279(2-3):171-7. PubMed PMID: 7556398.