KI-MS2-008 | Max-Binding Modulator

MedKoo Cat#: 558707 | Name: KI-MS2-008

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KI-MS2-008 is a Max-binding modulator, attenuating Myc-driven transcription and stabilizing the Max homodimer.

Chemical Structure

KI-MS2-008

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 558707

Name: KI-MS2-008

CAS#: NONE

Chemical Formula: C32H28N2O4S

Exact Mass: 536.1770

Molecular Weight: 536.65

Elemental Analysis: C, 71.62; H, 5.26; N, 5.22; O, 11.93; S, 5.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KI MS2-008; KI-MS2 008; KI-MS2-008; KI MS2008; KI-MS2008; KI-MS2008;

IUPAC/Chemical Name

(3aS,10bS)-3a-Benzyl-2-phenyl-5-(2-(phenylsulfonyl)ethyl)-3a,5,6,10b-tetrahydro-4H-benzo[c]oxazolo[5,4-e]azepin-4-one

InChi Key

AUPOISKEBNQLRH-NYDCQLBNSA-N

InChi Code

InChI=1S/C32H28N2O4S/c35-31-32(22-24-12-4-1-5-13-24)29(38-30(33-32)25-14-6-2-7-15-25)28-19-11-10-16-26(28)23-34(31)20-21-39(36,37)27-17-8-3-9-18-27/h1-19,29H,20-23H2/t29-,32-/m0/s1

SMILES Code

O=C1[C@]2(CC3=CC=CC=C3)[C@](OC(C4=CC=CC=C4)=N2)([H])C5=CC=CC=C5CN1CCS(=O)(C6=CC=CC=C6)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 536.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Boyd SR, Young DW. Max-imizing the Attenuation of Myc Using Small Molecules. Trends Pharmacol Sci. 2019 Sep;40(9):608-612. doi: 10.1016/j.tips.2019.06.002. Epub 2019 Jul 4. PubMed PMID: 31280901. 2: Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, Curtin BH, Tseng H, Frombach KR, Butty VL, Levine SS, Feau C, Elmiligy S, Hong JA, Lewis TA, Vetere A, Clemons PA, Malstrom SE, Ebert BL, Lin CY, Felsher DW, Koehler AN. Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chem Biol. 2019 May 16;26(5):711-723.e14. doi: 10.1016/j.chembiol.2019.02.009. Epub 2019 Mar 14. PubMed PMID: 30880155.