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MedKoo Cat#: 326786 | Name: Kanamycin A sulfate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kanamycin, also known as kanamycin A, is an aminoglycoside bacteriocidal antibiotic, available in by mouth, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes. It gives birth to substantial amounts of mistranslation and indirectly inhibits translocation during protein synthesis.

Chemical Structure

Kanamycin A sulfate
Kanamycin A sulfate
CAS#25389-94-0 (sulfate)

Theoretical Analysis

MedKoo Cat#: 326786

Name: Kanamycin A sulfate

CAS#: 25389-94-0 (sulfate)

Chemical Formula: C18H38N4O15S

Exact Mass: 582.2054

Molecular Weight: 582.58

Elemental Analysis: C, 37.11; H, 6.57; N, 9.62; O, 41.19; S, 5.50

Price and Availability

Size Price Availability Quantity
1g USD 150.00 2 Weeks
2g USD 250.00 2 Weeks
5g USD 350.00 2 Weeks
10g USD 650.00 2 Weeks
20g USD 950.00 2 Weeks
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Related CAS #
25389-94-0 (sulfate) 59-01-8 (free base) 11025-65-3 19079-03-9 64013-69-0 936337-76-7
Synonym
Kanamycin sulfate; kanamycin A sulfate; Kanabristol; Kanacedin; Kanamycin monosulfate; Kanamycin (sulfate)
IUPAC/Chemical Name
(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4,5-triol sulfate
InChi Key
OOYGSFOGFJDDHP-KMCOLRRFSA-N
InChi Code
InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
SMILES Code
N[C@@H]1[C@@H](O[C@@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CN)O2)[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](N)C1.OS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2941.90.1010
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Water 34.4 58.95
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 582.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Robati RY, Arab A, Ramezani M, Langroodi FA, Abnous K, Taghdisi SM. Aptasensors for quantitative detection of kanamycin. Biosens Bioelectron. 2016 Aug 15;82:162-72. doi: 10.1016/j.bios.2016.04.011. Epub 2016 Apr 5. Review. PubMed PMID: 27085947. 2: Qin X, Yin Y, Yu H, Guo W, Pei M. A novel signal amplification strategy of an electrochemical aptasensor for kanamycin, based on thionine functionalized graphene and hierarchical nanoporous PtCu. Biosens Bioelectron. 2016 Mar 15;77:752-8. doi: 10.1016/j.bios.2015.10.050. Epub 2015 Oct 23. Review. PubMed PMID: 26513281. 3: Guo W, Sun N, Qin X, Pei M, Wang L. A novel electrochemical aptasensor for ultrasensitive detection of kanamycin based on MWCNTs-HMIMPF6 and nanoporous PtTi alloy. Biosens Bioelectron. 2015 Dec 15;74:691-7. doi: 10.1016/j.bios.2015.06.081. Epub 2015 Jul 10. Review. PubMed PMID: 26208174. 4: Feng Y, Liu S, Wang Q, Wang L, Tang S, Wang J, Lu W. Rapid diagnosis of drug resistance to fluoroquinolones, amikacin, capreomycin, kanamycin and ethambutol using genotype MTBDRsl assay: a meta-analysis. PLoS One. 2013;8(2):e55292. doi: 10.1371/journal.pone.0055292. Epub 2013 Feb 1. Review. PubMed PMID: 23383320; PubMed Central PMCID: PMC3562191. 5: Yin Z, Kng W. [Research progress of acute kanamycin sulfate-induced deafness in guinea pig]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;26(10):478-80. Review. Chinese. PubMed PMID: 22870728. 6: Georghiou SB, Magana M, Garfein RS, Catanzaro DG, Catanzaro A, Rodwell TC. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review. PLoS One. 2012;7(3):e33275. doi: 10.1371/journal.pone.0033275. Epub 2012 Mar 29. Review. PubMed PMID: 22479378; PubMed Central PMCID: PMC3315572. 7: Kanamycin. Tuberculosis (Edinb). 2008 Mar;88(2):117-8. doi: 10.1016/S1472-9792(08)70012-X. Review. PubMed PMID: 18486046. 8: Hoffmann JJ. EDTA-induced pseudo-neutropenia resolved with kanamycin. Clin Lab Haematol. 2001 Jun;23(3):193-6. Review. PubMed PMID: 11553062. 9: Nap JP, Bijvoet J, Stiekema WJ. Biosafety of kanamycin-resistant transgenic plants. Transgenic Res. 1992 Nov;1(6):239-49. Review. PubMed PMID: 1301215. 10: Lemieux RU, Bock K. The conformations of the Lewis blood group determinants, sucrose and kanamycin A. Jpn J Antibiot. 1979 Dec;32 Suppl:S163-77. Review. PubMed PMID: 95123. 11: Brewer NS. Antimicrobial agents--Part II. The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, neomycin. Mayo Clin Proc. 1977 Nov;52(11):675-9. Review. PubMed PMID: 336988. 12: Clark CH. Clinical uses of kanamycin, neomycin and streptomycin. Mod Vet Pract. 1977 Oct;58(10):845-50. Review. PubMed PMID: 73127. 13: Okamoto N, Suzuki Y. [Chloramphenicol, dihydrostreptomycin and kanamycin inactivating enzymes of R-factor resistant bacteria]. Nihon Saikingaku Zasshi. 1970 Nov;25(11):581-90. Review. Japanese. PubMed PMID: 4923678. 14: Bunn PA. Kanamycin. Med Clin North Am. 1970 Sep;54(5):1245-56. Review. PubMed PMID: 4919151. 15: Kuznetsova SM, Fomina IP, Navashin SM. [Kanamycin in the treatment of suppurative-septic infections]. Antibiotiki. 1970 Apr;15(4):360-74. Review. Russian. PubMed PMID: 4926437. 16: Kuznetsova SM, Fomina IP, Navashin SM. [Kanamycin in the treatment of suppurative-septic infections]. Antibiotiki. 1970 Apr;15(4):360-74. Review. Russian. PubMed PMID: 4924723. 17: Baker GL. Management of neonatal bacterial infections. Rx: continual alertness, specific treatment, and ampicillin with kanamycin until the culture reports are back. Clin Pediatr (Phila). 1969 Oct;8(10):575-9. Review. PubMed PMID: 4899101. 18: Simon HJ. Streptomycin, kanamycin, neomycin and paromomycin. Pediatr Clin North Am. 1968 Feb;15(1):73-83. Review. PubMed PMID: 4866908. 19: Donomae I. [Clinical evaluation of kanamycin in the last 10 years]. Nihon Ishikai Zasshi. 1967 Dec 15;58(12):1397-400. Review. Japanese. PubMed PMID: 4875598. 20: Sorensen AW. [Kanamycin. A review]. Ugeskr Laeger. 1966 Sep 1;128(35):1011-6. Review. Danish. PubMed PMID: 5330594.

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