MedKoo Cat#: 565586 | Name: YZ129

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YZ129 is a novel hsp90 inhibitor, targeting the calcineurin-nfat signaling and hsp90 client network for glioblastoma (gbm) therapy

Chemical Structure

YZ129
YZ129
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565586

Name: YZ129

CAS#: N/A

Chemical Formula: C19H12N2O2

Exact Mass: 300.0899

Molecular Weight: 300.32

Elemental Analysis: C, 75.99; H, 4.03; N, 9.33; O, 10.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
YZ129; YZ 129; YZ-129
IUPAC/Chemical Name
4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione
InChi Key
NYDMVPHEEBVAHT-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H12N2O2/c22-18-10-17(15-3-1-2-4-16(15)19(18)23)21-14-6-5-13-11-20-8-7-12(13)9-14/h1-11,21H
SMILES Code
O=C1C(C=C(NC2=CC3=C(C=NC=C3)C=C2)C4=C1C=CC=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu Z, Li H, He L, Xiang Y, Tian C, Li C, Tan P, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, Zhou Y. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2019 Mar 21;26(3):352-365.e7. doi: 10.1016/j.chembiol.2018.11.009. Epub 2019 Jan 10. PubMed PMID: 30639261; PubMed Central PMCID: PMC6430684.