JNJ-39933673, also known as TA-1887, is a SGLT inhibitor. TA-1887 antagonizes diabetic cachexia and decreases mortality. TA-1887 treatment prevented pancreatic beta cell death, enhanced preservation of beta cell mass and endogenous insulin secretion, and increased insulin sensitivity. Moreover, TA-1887 treatment attenuated inflammation, oxidative stress, and cellular senescence, especially in visceral white adipose tissue, and antagonized endothelial dysfunction.
MedKoo Cat#: 525401
Name: JNJ-39933673
CAS#: 1003005-29-5 (free)
Chemical Formula: C24H26FNO5
Exact Mass: 427.1795
Molecular Weight: 427.47
Elemental Analysis: C, 67.43; H, 6.13; F, 4.44; N, 3.28; O, 18.71
The following data is based on the product molecular weight 427.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
