Kinamycin C | CAS#35303-08-3 | anticancer agent

MedKoo Cat#: 558524 | Name: Kinamycin C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kinamycin C is a bacterial metabolite that acts as an anticancer agent.

Chemical Structure

Kinamycin C

CAS#35303-08-3

Theoretical Analysis

MedKoo Cat#: 558524

Name: Kinamycin C

CAS#: 35303-08-3

Chemical Formula: C24H20N2O10

Exact Mass: 496.1100

Molecular Weight: 496.43

Elemental Analysis: Chemical Formula: C24H20N2O10 Exact Mass: 496.11 Molecular Weight: 496.43 Elemental Analysis: C, 58.07; H, 4.06; N, 5.64; O, 32.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Kinamycin C; KinamycinC; Kinamycin-C;

IUPAC/Chemical Name

5H-Benzo(b)carbazole-5-carbonitrile, 1,2,4-tris(acetyloxy)-1,2,3,4,6,11-hexahydro-3,7-dihydroxy-3-methyl-6,11-dioxo-, (1-alpha,2-beta,3-alpha,4-alpha)-

InChi Key

BQWLWNOFIHHESO-SBFWRKJZSA-N

InChi Code

InChI=1S/C24H20N2O10/c1-9(27)34-21-16-15-17(20(32)14-12(19(15)31)6-5-7-13(14)30)26(8-25)18(16)22(35-10(2)28)24(4,33)23(21)36-11(3)29/h5-7,21-23,30,33H,1-4H3/t21-,22+,23+,24+/m1/s1

SMILES Code

N#CN1C(C(C2=C(O)C=CC=C23)=O)=C(C4=C1[C@H](OC(C)=O)[C@](C)(O)[C@@H](OC(C)=O)[C@@H]4OC(C)=O)C3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 496.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hasinoff BB, Wu X, Yalowich JC, Goodfellow V, Laufer RS, Adedayo O, Dmitrienko GI. Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects. Anticancer Drugs. 2006 Aug;17(7):825-37. PubMed PMID: 16926632. 2: Omura S, Nakagawa A, Yamada H, Hata T, Furusaki A. Structures and biological properties of Kinamycin A, B, C, and D. Chem Pharm Bull (Tokyo). 1973 May;21(5):931-40. PubMed PMID: 4727361. 3: Lei X, Porco JA Jr. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. J Am Chem Soc. 2006 Nov 22;128(46):14790-1. PubMed PMID: 17105273. 4: Nicolaou KC, Li H, Nold AL, Pappo D, Lenzen A. Total synthesis of kinamycins C, F, and J. J Am Chem Soc. 2007 Aug 29;129(34):10356-7. Epub 2007 Aug 4. PubMed PMID: 17676854. 5: Scully SS, Porco JA Jr. Studies toward the synthesis of the epoxykinamycin FL-120B': discovery of a decarbonylative photocyclization. Org Lett. 2012 May 18;14(10):2646-9. doi: 10.1021/ol3010563. Epub 2012 May 9. PubMed PMID: 22571279; PubMed Central PMCID: PMC3433630.