Synonym
APD597; APD-597; APD 597; JNJ-38431055; JNJ 38431055; JNJ38431055.
IUPAC/Chemical Name
isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate
InChi Key
WPDCHTSXOPUOII-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
SMILES Code
CC1=NC(S(C)(=O)=O)=CC=C1NC2=NC=NC(OC3CCN(C(OC(C)C)=O)CC3)=C2OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
479.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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Tung SF, Chang S, Chuang CF, Morgan M, Sadeque A, Chu ZL, Leonard JN, Jones RM.
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.
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Epub 2014 Jul 3. PubMed PMID: 25088191.
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Demarest K, Jones RM. Discovery of a second generation agonist of the orphan
G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett.
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PubMed PMID: 22264481.
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of type 2 diabetes. Expert Opin Ther Pat. 2009 Oct;19(10):1339-59. doi:
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