MedKoo Cat#: 526769 | Name: GW791343 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW791343 is a P2X7 allosteric modulator. GW791343 exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.

Chemical Structure

GW791343 HCl
GW791343 HCl
CAS#1019779-04-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 526769

Name: GW791343 HCl

CAS#: 1019779-04-4 (HCl)

Chemical Formula: C20H27Cl3F2N4O

Exact Mass:

Molecular Weight: 483.81

Elemental Analysis: C, 49.65; H, 5.63; Cl, 21.98; F, 7.85; N, 11.58; O, 3.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
309712-55-8 (HCl) 1019779-04-4 (HCl) 309712-73-0 (free base)
Synonym
GW791343; GW 791343; GW-791343; GW791343 trihydrochloride; GW791343 HCl.
IUPAC/Chemical Name
2-((3,4-difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide trihydrochloride
InChi Key
WSBRAHWNJBXXJM-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24F2N4O.3ClH/c1-14-2-3-15(13-26-8-6-23-7-9-26)10-19(14)25-20(27)12-24-16-4-5-17(21)18(22)11-16;;;/h2-5,10-11,23-24H,6-9,12-13H2,1H3,(H,25,27);3*1H
SMILES Code
CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 483.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Habermacher C, Dunning K, Chataigneau T, Grutter T. Molecular structure and function of P2X receptors. Neuropharmacology. 2016 May;104:18-30. doi: 10.1016/j.neuropharm.2015.07.032. Epub 2015 Jul 29. Review. PubMed PMID: 26231831. 2: Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. Mechanism of action of species-selective P2X(7) receptor antagonists. Br J Pharmacol. 2009 Apr;156(8):1312-25. doi: 10.1111/j.1476-5381.2009.00135.x. Epub 2009 Mar 20. PubMed PMID: 19309360; PubMed Central PMCID: PMC2697735. 3: Michel AD, Clay WC, Ng SW, Roman S, Thompson K, Condreay JP, Hall M, Holbrook J, Livermore D, Senger S. Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects. Br J Pharmacol. 2008 Nov;155(5):738-51. doi: 10.1038/bjp.2008.306. Epub 2008 Jul 28. PubMed PMID: 18660826; PubMed Central PMCID: PMC2584934. 4: Michel AD, Chambers LJ, Walter DS. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol. 2008 Feb;153(4):737-50. Epub 2007 Dec 10. PubMed PMID: 18071294; PubMed Central PMCID: PMC2259211.