BQ788 | CAS#156161-89-6 | ndothelin B receptor antagonist

MedKoo Cat#: 526691 | Name: BQ788 sodium salt

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BQ788 is a endothelin B receptor antagonist. BQ788 attenuates stab wound injury-induced reactive astrocytes in rat brain. BQ788 were well tolerated and showed signs of directly and indirectly reducing the viability of melanoma cells.

Chemical Structure

BQ788 sodium salt

CAS#156161-89-6

Theoretical Analysis

MedKoo Cat#: 526691

Name: BQ788 sodium salt

CAS#: 156161-89-6

Chemical Formula: C34H50N5NaO7

Exact Mass: 0.0000

Molecular Weight: 663.79

Elemental Analysis: C, 61.52; H, 7.59; N, 10.55; Na, 3.46; O, 16.87

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 550.00	2 Weeks
10mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

BQ788; BQ-788; BQ 788; BQ 788 sodium; BQ788 sodium; BQ-788 sodium

IUPAC/Chemical Name

sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate

InChi Key

QCVIFBRTTLMEOV-FUKQNADPSA-M

InChi Code

InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1

SMILES Code

CCCC[C@H](C([O-])=O)NC([C@@H](CC1=CN(C(OC)=O)C2=C1C=CC=C2)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 156161-89-6(BQ-788 sodium salt) 173326-37-9(BQ-788 Free base)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 663.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wouters J, Hunger RE, Garrod T, Dubuis B, Hunziker T, van den Oord JJ, Lahav-le Coutre R. First-in-Human Proof-of-Concept Study: Intralesional Administration of BQ788, an Endothelin Receptor B Antagonist, to Melanoma Skin Metastases. Oncologist. 2015 Oct;20(10):1121-2. doi: 10.1634/theoncologist.2015-0139. Epub 2015 Sep 1. PubMed PMID: 26330458; PubMed Central PMCID: PMC4591941. 2: Liang Y, Cai Y. Effects of endothelin B receptor antagonists, BQ788 and ET-1(11-21) fragment on the bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs. Chin Med J (Engl). 2000 Mar;113(3):217-21. PubMed PMID: 11775249. 3: Koyama Y, Takemura M, Fujiki K, Ishikawa N, Shigenaga Y, Baba A. BQ788, an endothelin ET(B) receptor antagonist, attenuates stab wound injury-induced reactive astrocytes in rat brain. Glia. 1999 May;26(3):268-71. PubMed PMID: 10340767. 4: Peter MG, Davenport AP. Characterization of the endothelin receptor selective agonist, BQ3020 and antagonists BQ123, FR139317, BQ788, 50235, Ro462005 and bosentan in the heart. Br J Pharmacol. 1996 Feb;117(3):455-462. PubMed PMID: 8821534; PubMed Central PMCID: PMC1909322.