LMP-744 HCl is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP-744 HCl produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP-744 HCl at nanomolar concentrations. Studies in human cells in culture found LMP-744 HCl to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP-744 HCl also exhibits antitumor activity in mouse tumor xenografts.
MedKoo Cat#: 599107
Name: LMP744 HCl
CAS#: 308246-57-3 (HCl)
Chemical Formula: C24H25ClN2O7
Exact Mass: 0.0000
Molecular Weight: 488.92
Elemental Analysis: C, 58.96; H, 5.15; Cl, 7.25; N, 5.73; O, 22.91
The following data is based on the product molecular weight 488.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
