Gly-Pro-Arg-Pro Acetate | CAS#67869-62-9 | fibrinogen aggregation inhibitor

MedKoo Cat#: 561710 | Name: Gly-Pro-Arg-Pro Acetate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gly-Pro-Arg-Pro Acetate is an inhibitor of fibrinogen aggregation that acts by binding to fibrinopeptide A.

Chemical Structure

Gly-Pro-Arg-Pro Acetate

CAS#67869-62-9

Theoretical Analysis

MedKoo Cat#: 561710

Name: Gly-Pro-Arg-Pro Acetate

CAS#: 67869-62-9

Chemical Formula: C20H35N7O7

Exact Mass: 0.0000

Molecular Weight: 485.54

Elemental Analysis: C, 49.47; H, 7.27; N, 20.19; O, 23.07

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 350.00	2 Weeks

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Synonym

Gly-Pro-Arg-Pro Acetate; GPRP; Gly-Pro-Arg-Pro Acetate salt; glycyl-prolyl-arginyl-proline;

IUPAC/Chemical Name

(S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid acetate

InChi Key

ZYTSTPIIKNCGRE-QKWXXBCPSA-N

InChi Code

InChI=1S/C18H31N7O5.C2H4O2/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30;1-2(3)4/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22);1H3,(H,3,4)/t11-,12-,13-;/m0./s1

SMILES Code

O=C([C@H]1N(C([C@@H](NC([C@H]2N(C(CN)=O)CCC2)=O)CCCNC(N)=N)=O)CCC1)O.CC(O)=O

Appearance

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa).

In vitro activity:

Glycyl-L-prolyl-L-arginyl-L-proline (gly-pro-arg-pro), a fibrin polymerization inhibitor, inhibited des A and des A,B fibrinogen from enhancing thrombin-catalyzed factor XIIIa formation. Reference: Blood. 1985 Aug;66(2):466-9. https://pubmed.ncbi.nlm.nih.gov/2861869/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	20.8	42.90

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 485.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Greenberg CS, Miraglia CC. The effect of fibrin polymers on thrombin-catalyzed plasma factor XIIIa formation. Blood. 1985 Aug;66(2):466-9. PMID: 2861869. 2. Crossen J, Diamond SL. Thermal shift assay to probe melting of thrombin, fibrinogen, fibrin monomer, and fibrin: Gly-Pro-Arg-Pro induces a fibrin monomer-like state in fibrinogen. Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129805. doi: 10.1016/j.bbagen.2020.129805. Epub 2020 Dec 1. PMID: 33276061; PMCID: PMC7752828.

In vitro protocol:

In vivo protocol:

TBD

1: Redlich H, Vickers J, Lösche W, Heptinstall S, Kehrel B, Spangenberg P. Formation of platelet-leukocyte conjugates in whole blood. Platelets. 1997;8(6):419-25. PubMed PMID: 16793677. 2: Ouyang XL, Liu JH, Luo Q, Shi Q, Han W, Li XJ, Gao D. [Flow cytometry combined assay for phosphatidylserine and CD62p expressed by preserved platelets]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002 Feb;10(1):66-9. Chinese. PubMed PMID: 12513841.