Zaltidine | CP-57,361 | CAS#85604-00-8 | 90274-23-0

MedKoo Cat#: 526579 | Name: Zaltidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zaltidine, also known as CP-57,361, is an effective but hepatotoxic H2-receptor antagonist. Zaltidine appears to be an effective treatment of duodenal ulcer. However, the incidence of hepatic damage (8%) seems higher than with commonly used H2-receptor antagonists.

Chemical Structure

Zaltidine

CAS#85604-00-8 (free base)

Theoretical Analysis

MedKoo Cat#: 526579

Name: Zaltidine

CAS#: 85604-00-8 (free base)

Chemical Formula: C8H10N6S

Exact Mass: 222.0688

Molecular Weight: 222.27

Elemental Analysis: C, 43.23; H, 4.54; N, 37.81; S, 14.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

85604-00-8 (free base) 90274-23-0 (HCl)

Synonym

Zaltidine; CP-57,361; CP 57,361; CP57,361; CP-57361; CP 57361; CP57361;CP-57361-01.

IUPAC/Chemical Name

1-(4-(2-methyl-1H-imidazol-4-yl)thiazol-2-yl)guanidine

InChi Key

GIMNAEMRNXUAQP-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H10N6S/c1-4-11-2-5(12-4)6-3-15-8(13-6)14-7(9)10/h2-3H,1H3,(H,11,12)(H4,9,10,13,14)

SMILES Code

NC(NC1=NC(C2=CNC(C)=N2)=CS1)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 85604-00-8 (Zaltidine free base) 90274-23-0 (Zaltidine hydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 222.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23(6):655-8. PubMed PMID: 2902681. 2: Laferla G, Buchanan N, Hearns J, Crean GP, McColl KE, Clucas AT. The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22(4):395-9. PubMed PMID: 2876724; PubMed Central PMCID: PMC1401146. 3: Hunter RP, Canning PC, Hassfurther R. Plasma analysis and pharmacokinetics of zaltidine, an H2-antagonist, in cattle after intravenous, intramuscular, subcutaneous, and oral administration. J Vet Pharmacol Ther. 1996 Aug;19(4):326-8. PubMed PMID: 8866466.