MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 526568 | Name: WAY-123398 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Way 123398 is a class III antiarrhythmic agent.

Chemical Structure

WAY-123398 free base
WAY-123398 free base
CAS#138490-53-6 (free base)

Theoretical Analysis

MedKoo Cat#: 526568

Name: WAY-123398 free base

CAS#: 138490-53-6 (free base)

Chemical Formula: C19H25N5O4S

Exact Mass: 451.1348

Molecular Weight: 451.56

Elemental Analysis: C, 50.54; H, 5.58; N, 15.51; O, 14.17; S, 14.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
138490-52-5 (HCl) 139702-24-2 (2HCl) 138490-53-6 (free base)
Synonym
Way123398; Way-123398; Way 123398; Way-123,398; Way123,398; Way 123,398
IUPAC/Chemical Name
N-methyl-N-(2-(methyl(1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-4-(methylsulfonamido)benzenesulfonamide
InChi Key
PELVIWZRAPOYAC-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H25N5O4S2/c1-22(19-20-17-7-5-6-8-18(17)24(19)3)13-14-23(2)30(27,28)16-11-9-15(10-12-16)21-29(4,25)26/h5-12,21H,13-14H2,1-4H3
SMILES Code
O=S(C1=CC=C(NS(=O)(C)=O)C=C1)(N(C)CCN(C)C2=NC3=CC=CC=C3N2C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 451.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liang XJ, Taylor B, Cardarelli C, Yin JJ, Annereau JP, Garfield S, Wincovitch S, Szakács G, Gottesman MM, Aszalos A. Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance. Anticancer Res. 2005 Nov-Dec;25(6B):4113-22. PubMed PMID: 16309205. 2: Finlayson K, Turnbull L, January CT, Sharkey J, Kelly JS. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen. Eur J Pharmacol. 2001 Oct 26;430(1):147-8. PubMed PMID: 11698075. 3: Higashida H, Brown DA, Robbins J. Both linopirdine- and WAY123,398-sensitive components of I K(M,ng) are modulated by cyclic ADP ribose in NG108-15 cells. Pflugers Arch. 2000 Dec;441(2-3):228-34. PubMed PMID: 11211107. 4: Finlayson K, Pennington AJ, Kelly JS. [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel? Eur J Pharmacol. 2001 Feb 2;412(3):203-12. PubMed PMID: 11166283. 5: Lee JH, Rosen MR. Alpha 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J Cardiovasc Electrophysiol. 1994 Mar;5(3):232-40. PubMed PMID: 8193739. 6: Spinelli W, Moubarak IF, Parsons RW, Colatsky TJ. Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes. Cardiovasc Res. 1993 Sep;27(9):1580-91. PubMed PMID: 8287434. 7: Ellingboe JW, Spinelli W, Winkley MW, Nguyen TT, Parsons RW, Moubarak IF, Kitzen JM, Von Engen D, Bagli JF. Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides. J Med Chem. 1992 Feb 21;35(4):705-16. PubMed PMID: 1542097. 8: Gullo F, Ales E, Rosati B, Lecchi M, Masi A, Guasti L, Cano-Abad MF, Arcangeli A, Lopez MG, Wanke E. ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J. 2003 Feb;17(2):330-2. Epub 2002 Dec 17. PubMed PMID: 12490549. 9: Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, Olivotto M, Pegoraro L, Arcangeli A. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia. 2002 Sep;16(9):1791-8. PubMed PMID: 12200695. 10: Cherubini A, Taddei GL, Crociani O, Paglierani M, Buccoliero AM, Fontana L, Noci I, Borri P, Borrani E, Giachi M, Becchetti A, Rosati B, Wanke E, Olivotto M, Arcangeli A. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br J Cancer. 2000 Dec;83(12):1722-9. PubMed PMID: 11104572; PubMed Central PMCID: PMC2363441. 11: Rosati B, Marchetti P, Crociani O, Lecchi M, Lupi R, Arcangeli A, Olivotto M, Wanke E. Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release. FASEB J. 2000 Dec;14(15):2601-10. PubMed PMID: 11099479. 12: Selyanko AA, Hadley JK, Wood IC, Abogadie FC, Delmas P, Buckley NJ, London B, Brown DA. Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J Neurosci. 1999 Sep 15;19(18):7742-56. PubMed PMID: 10479678. 13: Meves H, Schwarz JR, Wulfsen I. Separation of M-like current and ERG current in NG108-15 cells. Br J Pharmacol. 1999 Jul;127(5):1213-23. PubMed PMID: 10455268; PubMed Central PMCID: PMC1566115. 14: Faravelli L, Arcangeli A, Olivotto M, Wanke E. A HERG-like K+ channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization. J Physiol. 1996 Oct 1;496 ( Pt 1):13-23. Erratum in: J Physiol (Lond) 1997 Aug 1;502(Pt 3):715. PubMed PMID: 8910192; PubMed Central PMCID: PMC1160820. 15: Spinelli W, Parsons RW, Colatsky TJ. Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol. J Cardiovasc Pharmacol. 1992 Dec;20(6):913-22. PubMed PMID: 1282594. 16: Becchetti A, De Fusco M, Crociani O, Cherubini A, Restano-Cassulini R, Lecchi M, Masi A, Arcangeli A, Casari G, Wanke E. The functional properties of the human ether-à-go-go-like (HELK2) K+ channel. Eur J Neurosci. 2002 Aug;16(3):415-28. PubMed PMID: 12193184.

View History

HAM-1

HAM-1