Verofylline | CAS#66172-75-6 | Bronchodilator

MedKoo Cat#: 526553 | Name: Verofylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Verofylline is a methylxanthine bronchodilator.

Chemical Structure

Verofylline

CAS#66172-75-6

Theoretical Analysis

MedKoo Cat#: 526553

Name: Verofylline

CAS#: 66172-75-6

Chemical Formula: C12H18N4O2

Exact Mass: 250.1430

Molecular Weight: 250.30

Elemental Analysis: C, 57.58; H, 7.25; N, 22.38; O, 12.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CK 0383; CK0383; CK-0383; Verofylline; Verofilina; Verofyllinum

IUPAC/Chemical Name

1,8-dimethyl-3-(2-methylbutyl)-3,7-dihydro-1H-purine-2,6-dione

InChi Key

MTBUJUHRXVGLEF-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H18N4O2/c1-5-7(2)6-16-10-9(13-8(3)14-10)11(17)15(4)12(16)18/h7H,5-6H2,1-4H3,(H,13,14)

SMILES Code

O=C(N1C)N(CC(C)CC)C2=C(NC(C)=N2)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 250.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Young RC Jr, Lucas SG, Morris EA, Pittman J, Rachal RE, Malveaux FJ, Booker WM. Verofylline, a methylxanthine bronchodilator, in asthma. Clin Pharmacol Ther. 1984 Dec;36(6):811-6. PubMed PMID: 6388955. 2: Shum L, Jusko WJ. Verofylline pharmacokinetics in dietary-induced obese rats: role of fat mass and protein binding in determining volume of distribution. Xenobiotica. 1991 Nov;21(11):1419-30. PubMed PMID: 1763516. 3: Shum L, Jusko WJ. Reversed-phase high-performance liquid chromatographic determination of verofylline in rat serum. J Chromatogr. 1986 Oct 31;382:207-13. PubMed PMID: 3782387. 4: Grassi C, Casali L, Rampulla C, Rossi A. Clinical efficacy trial: theophylline vs (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione. Int J Clin Pharmacol Ther Toxicol. 1980 Dec;18(12):518-22. PubMed PMID: 7014478. 5: Grassi C, Casali L, Rampulla C, Rossi A. Effect of (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione on exercise-induced bronchospasm. Int J Clin Pharmacol Ther Toxicol. 1981 Jul;19(7):297-302. PubMed PMID: 7263107. 6: Cho YW, Han HC, OH SY, Maines JE 3rd, Kuemmerle HP. A double-blind, placebo-controlled evaluation of (dl)-3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione in exercise-induced bronchospasm. Int J Clin Pharmacol Ther Toxicol. 1981 Jun;19(6):266-72. PubMed PMID: 7030974.