Synonym
GT863; GT 863; GT-863; G T863; G-T863
IUPAC/Chemical Name
6-((E)-2-(5-((E)-2-methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-3-yl)vinyl)-1H-indole
InChi Key
AMBZHNVCLPHAKA-NSJFVGFPSA-N
InChi Code
InChI=1S/C28H24N4O2/c1-33-28-18-26(34-19-25-4-2-3-14-29-25)12-9-22(28)8-11-24-17-23(31-32-24)10-6-20-5-7-21-13-15-30-27(21)16-20/h2-18,30H,19H2,1H3,(H,31,32)/b10-6+,11-8+
SMILES Code
COC1=CC(OCC2=CC=CC=N2)=CC=C1/C=C/C3=CC(/C=C/C4=CC(NC=C5)=C5C=C4)=NN3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
448.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Kato H, Sato H, Okuda M, Wu J, Koyama S, Izumi Y, Waku T, Iino M, Aoki M, Arawaka S, Ohta Y, Ishizawa K, Kawasaki K, Urano Y, Miyasaka T, Noguchi N, Kume T, Akaike A, Sugimoto H, Kato T. Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Dec 11:1-7. doi: 10.1080/21678421.2021.2012699. Epub ahead of print. PMID: 34894926.
2. Urano Y, Takahachi M, Higashiura R, Fujiwara H, Funamoto S, Imai S, Futai E, Okuda M, Sugimoto H, Noguchi N. Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation. Cells. 2020 Feb 3;9(2):349. doi: 10.3390/cells9020349. PMID: 32028683; PMCID: PMC7072163.
