JNJ-61432059 is a TARP γ‑8 Selective AMPAR Negative Modulator with PIC50 = 9.7. JNJ-61432059 exhibited time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, which resulted in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.
MedKoo Cat#: 555403
Name: JNJ-61432059
CAS#: 2035814-50-5
Chemical Formula: C25H22FN5O2
Exact Mass: 443.1758
Molecular Weight: 443.48
Elemental Analysis: C, 67.71; H, 5.00; F, 4.28; N, 15.79; O, 7.22
The following data is based on the product molecular weight 443.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
