Omtriptolide | CAS#195883-06-8

MedKoo Cat#: 341173 | Name: Omtriptolide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Omtriptolide is a biochemical.

Chemical Structure

Omtriptolide

CAS#195883-06-8

Theoretical Analysis

MedKoo Cat#: 341173

Name: Omtriptolide

CAS#: 195883-06-8

Chemical Formula: C24H28O9

Exact Mass: 460.1733

Molecular Weight: 460.48

Elemental Analysis: C, 62.60; H, 6.13; O, 31.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Omtriptolide; YM 262; YM-262; YM262.

IUPAC/Chemical Name

UNII-D36ELM729P

InChi Key

HROMYAWHLUOUPY-AHCCQAQQSA-N

InChi Code

InChI=1S/C24H28O9/c1-10(2)22-17(32-22)18-24(33-18)21(3)7-6-11-12(9-29-19(11)28)13(21)8-14-23(24,31-14)20(22)30-16(27)5-4-15(25)26/h10,13-14,17-18,20H,4-9H2,1-3H3,(H,25,26)/t13-,14-,17-,18-,20+,21-,22-,23+,24+/m0/s1

SMILES Code

CC(C)[C@]12O[C@H]1[C@@H]3O[C@@]34[C@@]5(C)CCC6=C(COC6=O)[C@@H]5C[C@@H]7O[C@]47[C@@H]2OC(=O)CCC(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 460.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349(3):518-25. doi: 10.1124/jpet.114.213769. Epub 2014 Apr 11. PubMed PMID: 24727856. 2: Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 1;186(1):72-81. doi: 10.1164/rccm.201109-1593OC. Epub 2012 May 10. PubMed PMID: 22582160; PubMed Central PMCID: PMC3400991. 3: Danel C, Duval C, Azaroual N, Vaccher C, Bonte JP, Bailly C, Landy D, Goossens JF. Complexation of triptolide and its succinate derivative with cyclodextrins: affinity capillary electrophoresis, isothermal titration calorimetry and 1H NMR studies. J Chromatogr A. 2011 Dec 2;1218(48):8708-14. doi: 10.1016/j.chroma.2011.10.007. Epub 2011 Oct 8. PubMed PMID: 22033106. 4: Chen G, Sun H, Arp J, Garcia B, Wang X, Wise Y, Liu W, Ramcharran S, Huang X, Xiang Y, Yang H, Fang Z, Madrenas J, Sudo Y, Tamura K, Zhong R. A synergistic effect between PG490-88 and tacrolimus prolongs renal allograft survival in monkeys. Am J Transplant. 2006 Apr;6(4):714-23. Erratum in: Am J Transplant. 2006 Jun;6(6):1498. Madenas, J [corrected to Madrenas, J]. PubMed PMID: 16539628. 5: Wang X, Sun H, Chen G, Liu W, Wise Y, Yung C, Sudo Y, Tamura K, Garcia B, Zhong R. Immunosuppression with a combination of pg490-88 and a subtherapeutic dose of FK506 in a canine renal allograft model. Transplantation. 2005 Jun 15;79(11):1537-44. PubMed PMID: 15940043. 6: Fisniku O, Pan F, Wynn C, Erickson LM, Crews G, Jang MS, Sudo Y, Tamura K, Kobayashi M, Benediktsson H, Jiang H. Protective effects of PG490-88 on chronic allograft rejection by changing intragraft gene expression profiles. Transplant Proc. 2005 May;37(4):1962-4. PubMed PMID: 15919518. 7: Pan F, Fisniku O, Wynn C, Erickson LM, Crews G, Jang MS, Sudo Y, Tamura K, Kobayashi M, Benediktsson H, Jiang H. PG490-88, a new immunosuppressant, effectively prevents acute and chronic rejection in rat renal allografts. Transplant Proc. 2005 Jan-Feb;37(1):134-6. PubMed PMID: 15808572. 8: Fidler JM, Li K, Chung C, Wei K, Ross JA, Gao M, Rosen GD. PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol Cancer Ther. 2003 Sep;2(9):855-62. PubMed PMID: 14555704. 9: Leonard CT, Soccal PM, Berry GJ, Doyle RL, Theodore J, Duncan SR, Rosen GD. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21(12):1314-8. PubMed PMID: 12490278. 10: Chen BJ, Chen Y, Cui X, Fidler JM, Chao NJ. Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. Transplantation. 2002 Jan 15;73(1):115-21. PubMed PMID: 11792990. 11: Chen BJ, Liu C, Cui X, Fidler JM, Chao NJ. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70(10):1442-7. PubMed PMID: 11118087.