Milameline HCl | CAS#139886-04-7 | Alzheimer's

MedKoo Cat#: 525628 | Name: Milameline HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Milameline is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that had being investigated for the treatment of Alzheimer's disease.

Chemical Structure

Milameline HCl

CAS#139886-04-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 525628

Name: Milameline HCl

CAS#: 139886-04-7 (HCl)

Chemical Formula: C8H15ClN2O

Exact Mass: 190.0873

Molecular Weight: 190.67

Elemental Analysis: C, 50.39; H, 7.93; Cl, 18.59; N, 14.69; O, 8.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

139886-32-1 (free base) 139886-04-7 (HCl)

Synonym

CI979; CI 979; CI-979; Milameline

IUPAC/Chemical Name

(E)-1-methyl-1,2,5,6-tetrahydropyridine-3-carbaldehyde O-methyl oxime hydrochloride

InChi Key

WEBMRZODPLSRKR-MLBSPLJJSA-N

InChi Code

InChI=1S/C8H14N2O.ClH/c1-10-5-3-4-8(7-10)6-9-11-2;/h4,6H,3,5,7H2,1-2H3;1H/b9-6+;

SMILES Code

CN1CC(/C=N/OC)=CCC1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 190.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Trollor JN, Sachdev PS, Haindl W, Brodaty H, Wen W, Walker BM. Combined cerebral blood flow effects of a cholinergic agonist (milameline) and a verbal recognition task in early Alzheimer's disease. Psychiatry Clin Neurosci. 2006 Oct;60(5):616-25. PubMed PMID: 16958947. 2: Jack CR Jr, Slomkowski M, Gracon S, Hoover TM, Felmlee JP, Stewart K, Xu Y, Shiung M, O'Brien PC, Cha R, Knopman D, Petersen RC. MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology. 2003 Jan 28;60(2):253-60. PubMed PMID: 12552040; PubMed Central PMCID: PMC2745302. 3: Zheng XM. Detecting regional cerebral blood flow changes in Alzheimer's patients after milameline treatment: activation or baseline SPECT? J Nucl Med Technol. 2002 Sep;30(3):118-22. PubMed PMID: 12186960. 4: Schwarz RD, Callahan MJ, Coughenour LL, Dickerson MR, Kinsora JJ, Lipinski WJ, Raby CA, Spencer CJ, Tecle H. Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J Pharmacol Exp Ther. 1999 Nov;291(2):812-22. PubMed PMID: 10525104. 5: Callahan MJ. Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys. Psychopharmacology (Berl). 1999 Jun;144(3):234-8. PubMed PMID: 10435389.